Study On The Synthesis Of Emodin Derivative

Emodin, a kind of 1,8-dihydroxy-anthraquinone derivative, belongs to compound ofanthraquinone just like cancer medication Adriamycin and Daunomycin. It exists in herbalmedicines such as Rhubarb, Polygonumcuspidatum and so on as one kind of functionelement. Emodin has many pharmacological functions such as immunoregulation,antibacterial, diminish inflammation and kill tumours.Emodin is named as 1,3,8-trihydroxy-6methyl anthraquinone, its molecular weight is270.23, and is the the chief part of of the dissociative anthraquinones contained in Rhubarb(0.01% in Rpalmatum, 0.096% in both Rpalmatumvartanguticum and Rofficinale). Thereare a lot of reports about Emodin in literatures both home and overseas. The interest in theEmodin is a result of the discovery of its pharmaceutical potential, such as the influence indigestive system, urologysystem, immunity, cordis and vassal functions. It is also used forcontroling some pathogenic microbes, diminishing inflammation and killing tumours.In this dissertation, the synthesis ways of emodin were studied, summarized andseveral feasible ways were designed. Comparing the ways, the second way using theoriginal raw materical (methy1 3,5-dimethoxy benzoate) synthesis the emodin derivativewas designed. The mechanisms of every reaction were studied, and the application andforeground of emodin and it's derivatives were viewed.The structure of the synthetic products were characterized by differential scanningcalorimetry(DSC), infrared(IR), mass spectra(MS) and ~1H nuclear magneticresonance(NMR), the results proved: the structures and performance indicate that theproducts conformed to the design requirement, though the yield of the first five reationswas comparatively high, but the later reations are really low .This can prognosticate thesynthesis design of using the original raw materical (methy1 3,5-dimethoxy benzoate),synthesize emodin derivatives was practical.