Synthesis And Bioactivity Investigation On Pentacoordinated Organotin(Ⅳ) Complexes Containing Tridentate Schiff Base Ligands

There has been growing interested in Organotin(IV) complexes because of their extensive bioactivities, especially anti–tumour activity, so its have recently increased attention. It is very important to synthesis different types of organotin complexes with different structures. For it can provide much knowledge about the antibacterial and antitumour activities of organotin complexes, and it also can help us to study the relationship between the bioactivities and the structures of the organotin compounds. In this paper, three series of heterocyclic pentcoordinated organotin(Ⅳ) Schiff base complexes have been synthesized, its antibacterial and antitumour activities were also investigated.1. Seven aminophenol Schiff bases have been synthesized by the reaction of salicylaldehyde, o–vanillin, 2-hydroxy-1-naphthaldehyde, 2,4-dihydroxybenzaldehyde, o-hydroxyacetophenone, 5-bromine salicylaldehyde, 3,5-dibromine salicylaldehyde with o-aminophenol in anhydrous ethanol respectively; Four aminobenzenethiol Schiff bases have been synthesized by the reaction of salicylaldehyde, o–vanillin, 2-hydroxy-1-naphthaldehyde, 2,4-dihydroxybenzaldehyde with o-aminobenzenethiol in hydrous ethanol respectively. Three aminobenzoic acid Schiff bases have been synthesized by reaction of salicylaldehyde, o–vanillin, 2-hydroxy-naphthaldehyde with o-aminobenzoic acid in an hydrous-ethanol respectively. Their structures were characterized.2. Dibenzyltin, diphenyltin dichloride and di–n–butyltin dichloride have been synthesized by the literature method. Twenty-one novel heterocyclic pentcoordinate organotin(Ⅳ) Schiff base complexes have been synthesized by the reaction of dibenzyltin dichloride, diphenyltin dichloride and di–n–butyltin dichloride with o -aminophenol Schiff bases in anhydrous methanol. Their structures were characterized.3. Twelve novel heterocyclic pentcoordinate organotin(Ⅳ) Schiff base complexes have been synthesized by the reaction of dibenzyltin dichloride, diphenyltin dichloride and di–n–butyltin dichloride with the o-aminobenzenethiol Schiff bases in anhydrous methanol. Their structures were characterized.4. Nine novel heterocyclic pentcoordinated organotin(Ⅳ) Schiff base complexes have been synthesized by the reaction of dibenzyltin dichloride, diphenyltin dichloride and di–n–butyltin dichloride with o-aminobenzoic acid Schiff bases in anhydrous methanol. Their structures were characterized.5. The antibacterial and antitumour activities of the objective compounds 1-12 were determined. The relationships between the bioactivities and the structures of the organotin compounds were also been studied.