Study On Synthesis Of Like-Biginelli Compounds Under Microwave Irradiation And Solvent-free Condition

Since the entry into the 21st century, society sustainable development and relating problems on ecology, environment, resources, economy and so on have ever increasing been a hot topic in the international society and have been elevated to a height of development strategy. In the process of the chemistry production, a lot of wasted liquid, gas and solid have been produced and do much pollution to our environment. Making the chemistry world put their attention to stop or decrease the production of the waste basically, i.e. the prevention of pollution originally, but not the remedy after pollution. This will put forward new demands upon the science and technology and also challenges to chemistry, especially compound chemistry. Making chemistry serve the sustainable development of the national economy without do harm to the environment and efficiently utilizing the source, is a meaningful job.It is well-known that organic solvent is flammability, volatility and toxicity. No matter letting or reclaiming, it will be harmful to the environment. But most organic reaction is performed in organic solvent .So it is very necessary to find an effective way to solve this problem. Solvent-free organic synthesize technology, due to its ability to reduce the pollution, now has become the hotspot in the organic synthesize studying. Also it is the important part in the green chemistry.The purpose of this dissertation is expanding the use of organic method without solvent in the organic synthesized field. We investigated the Bigmelli reaction by microwave radiation method without solvent emphasizedlly. Using acetophenone,oxaloacetic acid in place of conventional Bigmelli reagent: ethyl acetoacetate (or acetylacetone). This method has gets satisfied result.This dissertation is classified into three chapters: Chapter 1 Literature SurveyIn this chapter we review the development and application in the area of microwave irradiation and solvent-free synthesis in recent years in detail.Chapter 2 Synthesis of 3,4-Dihydropyrimidinones catalyzed by concentrated sulfuric acid under microwave irradiation This chapter reported the synthesis of ten 3,4-Dihydropyrimidinones with high yields. They have been synthesized by the Biginelli condensation reaction of aromatic aldehyde, urea and ethyl acetoacetate catalyzed by concentrated sulfuric acid under microwave irradiation and solvent-free conditions. This method has the green synthesize characteristic. For not only the reaction condition is tender, the reaction time is shorter, but also avoid using the expensive catalyst. And the disposal process is simple; avoid the use of solvent which can pollute the environment.Chapter 3 microwave radiation method without solvent to synthesize a kin Biginelli compounds.This chapter reported the synthesis of sixteen kin Biginelli compounds with high yields. They have been synthesized by the Biginelli condensation reaction of aromatic aldehyde, aromatic ketone and urea catalyzed by zinc iodide under microwave irradiation and solvent-free conditions. Using oxaloacetic acid in place of ethyl acetoacetate catalyzed by zinc iodide synthesized nine kin Biginelli compounds by the microwave method without solvent. With this method not only the reaction condition is tender, the reaction time is shorter, but also it avoid using the expensive catalyst. And the disposal process is simple, avoid the use of solvent which can pollute the environment, this method accord with the green synthesize request.