Study On The Synthetic Technology Of Cefepime Dihydrochloride

The development and mechanism of antibiotic agents was described briefly in this paper. Cefepime dihydrochloride, one of fourth-generation cephalosporins, was introduced in detail, including its antibiotic mechanism, pharmacological properties and clinical effects. The synthetic process of cefepime dihydrochloride was researched particularly. After investigation of a series of synthetic routes of cefepime, we determined the best route and researched each step of the synthetic process for the goal of cost-cut, simplifying operation procedure and improving yield.We chose cyclohexane as the solvent of one-pot procedure of preparing 7- amino -3-(1-methylpyrrolidinio)methyl-3-cephem-4-carboxylate hydrochloride which was the key intermediate of cefepime in an overall yield of 21% scarcely with undesirable byproductΔ~3isomer. This procedure was simple, mild, environment-friendly, and suitable for scale-up production.We designed also a new procedure for the synthesis of cefepime dihydrochloride and obtained crude product in good yield. But it was dark-colored and need to be further optimized.The mechanism of byproductΔ~3 isomer produced was also preliminary speculate, and we found that theΔ~3 isomer could be seriously reduced by controlling proper reaction time and temperature. The MS characteristic of the product was analyzed and discussed in detail.