Study Of Preparation Technology And Quality Standard On Toutongxining Capsule

Migraine, a kind of common headache, is a sort of vascular headache,which occurs from time to time with headaches in one side or both sidesof the head, and is often accompanied with dizziness, nausea, vomitingand photophobia when it comes. At present, since migraine's incidence isgrowing and it is easy to occur repeatedly, so far there are few westernmedications which are effective in treating migraine. But ChineseMedicine accordingly is drawing much attention with its own advantages.There are many Chinese traditional medicine thai can treat migraine inthe market, such as Zhengtian Pill, Zhennaoning Capsule and etc. Thecapsule has effect of calming the liver, depriving the evil wetness andeliminating phlegm, improving acuity of vision and alleviating pain. Itis used for migraine caused by nerve, blood stasis and hypertension. Ithas remarkable curative effect and small harmful reaction through longclinical practice. However, It has many effects, such as taking largedosages every day, harmful smell and inconvenient to eat and so on. SoI study it.The experiment analyzed the clinical experienced prescription,do the experiment on extraction and preparation, established theduality standard frog Chp. and other documents, checked the stabilityto prove that the preparation is workable and did the test of thetoxicity.Take water and alcohol as solvent to extract medical material in theprescription respectively and cull solvent. Through orthogonal test, Iestablish optimum extraction process: alcohol extraction processconsists of 6 folds 50％alcohol, refluxing for 3 times and 1.5h each time.Meantime, study vacuum dryness temperature. The result shows thatGastrodine is relative steady in sample when dryness temperature is 60℃.Adapt TLC to distinguish four herbs, examine each index on the basis of the rule of capsule in Chinese Pharmaceustics 2005. Adapt HPLC toexamine Gastrodine content in sample, carry methology review andestablish quality controlled standard: Gastrodine content in sample is3.72mg each capsule, average recovery is 98.16％, RSD:0.43％.The drug effect learns to show in experiment that the curative effectof Toutongxining Capsule treating migraine is definite. Acute toxicityexperiment shows that the toxicity of Toutongxining Capsule is very small.So, it is reasonable and feasible to preparation technology and itis stable and dependable to standard quality through preparationtechnology and quality standard study, and there is no poisonous sideeffect when taking the drug for a long time. These can be applied.