One-pot Synthesis Of Benzofurans Under Microwave

Microwave heating has been used for the rapid synthesis of a variety of compound because the coupling of MW irradiation with the use of catalysts or mineral supported reagents, under solvent-free conditions, provide unique chemical processes with special attributes such as enhanced reaction rates, higher yields, greater selectivity and the ease of manipulation.Benzofurans possessing a broad range of biological activities, are constituents of important natural products, and have been the subject of extensive experimental studies. The expeditious solventless synthesis of functionalized benzofurans is described from readily accessible phenacyl bromide and phenols in processes that are accelerated by exposure to microwave.The Dazens reaction consists of condensation of aldehydes or ketones with -halocarboxylic acid esters in the presence of bases to give glycidic esters. The classical Dazens reaction has attracted interest because it is widely used in the synthesis of numerous biologically active natural compounds. At present, we improved the Dazens reaction. We ultilized phenacyl bromide (methyl bromoacetate) and benzealdehyde to formα,β-epoxy-carbonyl compounds under grinding at room temperature. The investigation is now undergoing in our laboratory.