Study On The Synthesis Of 4-hydroxy-3-methoxyphenyl Acetonitrile-A Key Intermediate Of Propanidid

Based on the review of the development of Intravenous anesthetics and the introduction of barbiturate and nonbarbiturate, the synthesis processes of Propanidid and its key intermediate 4-hydroxy-3-methoxyphenylacetonitrile has been summarized in the thesis.By analysis of the synthesis processes of 4-hydroxy-3-methoxyphenylacetonitrile, the process with vanillin as a start material was determined. Through a series of reactions, such as protection of hydroxyl, reduction, chloridization and nitrilation, the target compound was prepared. The influences of various reaction conditions on the yield were investigated, and the optimal reaction conditions (reagent, temperature, reaction time and yield) were obtained. The overall yield of 4-hydroxy-3-methoxyphenylacetonitrile is 58.7%.At the meantime, we tried another route: Beginning from the raw material — vanillin, 4-hydroxy-3-methoxyphenylacetonitrile was prepared, via reaction with phenylamine to form Shiff base, then reduction and nitrilation. The overall yield of 4-hydroxy-3-methoxyphenylacetonitrile is 67.2%.