Synthesis Of L-Thyroxine And Decyl-(1,2,3,4,5,6,7,8-octahydro-acridin-9-yl)-amine Derivatives

The thesis is divided into two parts, dealing with the development of anindustrially applicable route for the synthesis of L-Thyroxine, a recentlymarketed drug for the treatment of thyroid ill and the synthesis ofDecyl-(1,2,3,4,5,6,7,8-octahydro-acridin-9-yl)-amine derivatives for thetreatment of Alzheimer's Disease, which are of interest as building blocks toafford focused library in lead compound screening in drug discovery. In the first part, a five-step synthetic route for L-Thyroxine is discussed.The efficient synthesis starts from L-tyrosine by a sequence of reactionsincluding iodo, acylation, esterify, coupling, deprotection, get the finalproduct,at the same time , optimize the reaction condition. The final productwas fully characterized by HPLC-MS, 1HNMR, Ir, optical rotation. In the second part, efficient synthetic route was evaluated for thepreparation of Decyl-(1,2,3,4,5,6,7,8-octahydro-acridin-9-yl)-aminederivatives , which is limited report we can find .through parallel reaction,wefind the factor which influence the reaction , It resulted in some informationuseful to developing better mothod for the preparation of this type ofmolecules.