Research Of Prepared Technics And Quality Standard Of YangShouDan Concentrated Pill

Alzheimers disease: is a kind of disease happened to various dementia symptoms in the old age, the brain functions goes fading down, and the basal pathology is the brain cell atrophies, the cognition function decreasing and the memory descending are clinic behaves. the point views of the Chinese medicine:The senile dementia happens because of the old-age's body power desceding , and the damage to the brain, producing various symptom;Coming from 《imperial medicine authority》 a famous prescription —YangShouDan , can make the body strong ,makethe hair black , and prolong the life of Alzheimers disease patients.Prescription is made up of the Chinese herbal medicine: Polygonum multiflorum , Cistanche salsa , Polygala tenuifolia, etc., according to the Chinese medicine theory, distill the physics and chemistry compositions of the Chinese herbal medicine, and use the modern craft. and clinic effects proves safe, dependable. According to SDA, the classification of the Chinese herbal medicine, natural medicine registeration and request, the concentrated pills of the YangShouDan . The modern Chinese herbal medicine compound prescribe product should guide in the traditional medicine theories, and can make the not traditional craft .The valid composition of herbal medicine is more complicated, to attain to get away with the unuseful composition most in herbal medicine, and reserve the valid composition, embody the comprehensive curative effect of the compound prescribe product, and then make the quantity of the finished product stable, safety, controllable, satisfy clinic request.Therefore, how to guide in the Chinese medicine pharmacology and use high new technique in carrying on the pharmacy research, is the point of this experiment and seems a little bit difficult.This experiment according to characteristics and the quantity requests of the pill, building up the evaluation index sign and foundation of methods, to look for the exaltation to the YangShouDan quantity and method inspissation pills.This topic discuss the prescription of YangShouDan , use the method of unifom recipe design, discussing the differnt prescriptions to prolong to the fruit fly life span, the result shows: Cistanche salsa cooperate with Morindaofficinalis How in the influence of the life span , p=0. 01281, have to statistics meaning. Its combination: XI: X2: X3: X4=0. 64310: 0. 72200: 0. 64580: 0.36456;The medicine withdraws the aspect originally the topic adopted just hand over the method of design, experiment the result use the DPS data to handle the system analysis, the result shows: the best to distill condition is A2B2ClD3, with Ethanol concentration 65%, and distill time as 0. 5 hours each time, distilling 3 times, an A (Ethanol concentration), C( distill time), D(distill times), p<0.05, all have statistics meaning;According to the Chinese medical dictionary of 2005, this topic is building YangShouDan concentrated pill quantity standard, Use microscope to distinguish the Angelicasinensis(01iv)Diels,and use the mothod of TLC to distinguish Polygonuramultif lorum Thunb and Lycuirn barbarummL. HPLC has been used to detect the content of 2, 3, 5,4l~ tetrahydroxystilbene-2-0-3-D-glucoside in the experiment. Reclaim rate is 99.9% ,RSD is 0.54. the result is stabilization method is reliable , and exactitudation is high. The concertration pill examinations of the Chinese Medical Dictionary of 2005 is including character, mosisture detect, weight difference, heavy metal, arsenic salt, dispel time limit, germ number, mildew number, large intestine bacilli. It make foundaton for the YangShouDan concentrated pill to qualty control.From the results montioned above, under the guidance of the theory of TCM. On the on the basis of clinic demand, the characcter of chief chemical components and the Practice of industrial Production, and utilizing the lastest achievements in science and technologyfully and flexibly, we successfully completed the pharmaceutical study of of YangShouDan concentrated Pill, and grounded a solid foundation for developing new drug!...