Axial Modification, Characterization And Application In Photodynamic Therapy Of Silicon(Ⅵ) Phthalocyanines

Photodynamic Therapy (PDT) is a new technique for the treatment of neoplastic and non-neoplastic diseases. The photosensitizer is key factor in PDT. It is considerable interest in Silicon(Ⅵ) phthalocyanines(SiPcs) axially modified for use as photosensitizers. The main reason is that axially substituted Pcs are easily prepared as the single isomers, which is very favorable for the purpose of development of new drugs. What is more, introduction of bulky substituents at the axial sites of Pcs has been shown to increase the solubility and reduce the intermolecularπ-πaggregation, which benefits their photosensitizing efficiency. However, the effects of axial groups of SiPcs on their photodynamic activities have not received much attention and remains little studied.In order to evaluate the effects,the preparation and properties of a series of novel SiPcs axially with various groups have been carried out in this dissertation. The main results are summarized as following.(1) Twenty seven axially substituted Silicon(Ⅵ)phthalocyanines have been synthesized, and characterized by elemental analysis, IR, UV/VIS, MS, HNMR and HPLC. Twenty five of these complexes have not been reported so far, according to the best of our knowledge. The axial substituents are diversiform, including pyrimidine, piperazine, piperidine, carboxylic acid, mide, adamantine derivates and so on.(2) Some physical and chemical properties involved PDT has been studied, including solubility, stabilities, molecule spectra and existing state, photosensitivity. The results show that:(1) The electronic absorption spectra of most compounds in DMF are typical for non-aggregated phthalocyanines,...