| A series of Pc 4 (HOSiPcOSi(CH3)2(CH2) 3N(CH3)2) related compounds consisting of OH-substituted derivatives (XSiPcOSi(CH3)2(CH2)3N(CH 3)2), Pc 4 salts ([HOSiPcOSi(CH3)2(CH 2)3NH(CH3)2]+X -) and Pc 4 OH-substituted derivative salts (([XSiPcOSi(CH3) 2(CH2)3NH(CH3)2] +X-) has been prepared. The salts have been synthesized by straightforward acid-base reactions. Solubility studies of the Pc 4, the OH-substituted derivatives, the Pc 4 salts and the OH-substituted derivative salts in representative organic solvents and in aqueous dispersant-containing solutions have been carried out. Different dosage forms of Pc 4 including a liquid salt, aqueous solutions, a mineral oil solution, gels, a cream, and water-swellable films have been formulated. In addition, membrane penetration studies of the formulation of Pc 4 used in a completed Phase I clinical trial done at University Hospitals of Cleveland have been conducted. Polyurethane, cellulose, polyvinylidene fluoride, silicone, pig keratome, and human roof blister membranes have been used in the study.; In unrelated work, the known polymers, chrysotile-derived trimethylsiloxy scroll polymer, [((CH3)3SiO)x(OH)1-x SiO1.5]n, C-M3, and chrysotile-derived vinyldimethylsiloxy scroll polymer, [((CH2=CH)(CH3) 2SiO)x(OH)1-xSiO1.5], C-VM2, have been made. Also, the new polymers chrysotile-derived trimethylsiloxy-3-cyanopropylmethylmethoxysiloxy scroll polymer, [((CH3)3SiO)x((NC(CH 2)3(CH3)(CH3O)SiO)x(OH) 1-x-ySiO1.5]n, C-M3-CMOM, and chrysotile-derived vinyldimethylsiloxy-3-cyanopropylmethylmethoxysiloxy scroll polymer, [((CH 2=CH)(CH3)2SiO)x(NC(CH2) 3(CH3)(CH3O)SiO)y (OH) 1-x-ySiO1.5], C-VM2-CMOM, have been made by a novel pendent group-exchange reaction. Finally, partially platinum-filled C-M3 scrolls have been prepared. |
