Synthesizing Of Ramification From Aspirin And Selenium

Selenium exists in human's body with the form of selenoamino acid and polypeptide. Absorbing appropriate selenium is related with cancer, heart and blood vessel illness, sugar diabetes, cataract, pakinson etc. Aspirin is usually used to treat fever heat, headache, neuralgia , rheumatoid arthritis etc. Aspirin can guard against thrombus' forming, arteriosclerosis , brain in blood-absence provisionally and miocardial infarction etc. The curative effects have been attached importance and approbated.Does it get twice the result with half the effort to appropriately integrate the two medicines provided with curative effect and cheap? Will it exert the respective speciality ? These are taken into account by pharmacology experts. Therefore, the author excogitates some synthesis courses of new compounds including selenium and aspirin based on medicament chemistry and coalition principle. The new compound is named 5-5'-diselenium monoacetyl salicylic acid and ascertained by IR ,UV and MALDI-TOF-MS, and its structure is: OOHThe compound is inhibiting to sarcoma and ascites tumour of white mice by pharmacology experiments, so it is worth researching deeply.Furthermore, the synthesis technique of masalazine is studied by orthogonal tests. And the greatest point is that the productivity of nitration is 30% more than traditionary method.