Studies On Synthesis And Biological Activity Of Neonicotin Derivatives Containing Phosphorus (Ⅱ)

Two types of novel asymmetric cyclic phosphoramides and cyclothiophosphorylthiourea derivatives containing substituted pyridine were synthesized via the condensation reactions of 2-chloro-4-substitutedphenyl-5, 5-dimethyl-l, 3, 2-dioxaphosphinane 2-sulfide with 3-aminomethylpyridine and by the addition reaction of trans 2-isothiocyano-4-substitutedphenyl-5, 5-dimethyl-2-sulfo-l, 3, 2-dioxaphosphinane to 3-aminomethylpyridine or 2-chloro-5-amino methylpyridine.The cis and trans isomers of the products were isolated by column chromatography on silica gel. The structures of the products were characterized by ~1H NMR, ~31P NMR, IR, MS and elemental analyses. The configuration of I 3 A was determined by X-ray diffraction analysis.The results of preliminary bioassay showed that the new compounds possess potential fungicidal activities, some compounds possess insecticidal activity to some extent.