Study On The Synthesis Of Octylamine

The synthesis of tert-Octylamine from diisobutene was studied in this paper. Reaction of diisobutene with acetonitrile under sulfuric acid catalysis gave N-1,1,3,3-tetramethylbutylacetamide, which was hydrolyzed to tert-Octylamine. For the preparation of the intermediate N-1,1,3,3-tetramethylbutylacetamide, the reaction can proceed in acetic acid as a solvent or in aqueous sulfuric acid without the presence of any organic solvent. Under optimized conditions, the yields of the intermediate were 82% and 90% for the in-solvent reaction and the without solvent reaction, respectively. In the literature the hydrolysis of the intermediate was carried in glycol and the yield under optimized conditions was 68%. It was found in our work that the intermediate could be hydrolyzed to tert-Octylamine in aqueous sodium hydroxide in an autoclave and yield as high as 83% can be obtained under optimized conditions. According to a calculation based on the above results, the raw material expense of producing 1 ton of tert-Octylamine using procedures developed in this paper was less than RMB ?0,000.