Structural Modification Of ZNQ-06 And Herbicidal Activities Of Its Derivatives

Further biological evaluation had been carried out on ZNQ-06, a herbicidal leading compound which was found in previous work of our research group. At a dose of 1.5kg/ha, it exhibited a broader herbicidal spectrum and good inhibiting rates and the results showed that it might act on weeds in a similar model to that of protoporphyrinogen oxidase-inhibiting herbicides.In order to improve the herbicidal activity of the leading compound, a typical moiety of protoporphyrinogen oxidase-inhibiting agents, aryl ether, was introduced to the sketch and a new series of compound were synthesized.The structures were confirmed by 1H NMR and elementary analysis.Preliminary herbicidal evaluations showed that all the synthesized compounds just give a poor inhibiting rate at 1000mg/L and much weaker than ZNQ-06 itself. The result suggests that chloro atom on 2 position of thiodiazole ring might be necessary to herbicidal activity.