Studies On Synthesis Process Of New Type Pesticide And Medicament Intermediate--Pentafluorobenzonitrile

Pentafluorobenzonitrile is one of the most important intermediate in synthesis of medication and pesticide. It is prepared from pentachluorobenzonitrile by using KF as fluoride to substitute chlorine in the presence of benzonitrile under high temperature. But owing to the low solubility of KF and rigor synthesis condition, and the parallel auxiliary reactions, the speed of reaction as well as the yield is very low. So there is no productive factory in china.During the study of synthesis of pentafluorobenzonitrile, The HPLC qualitative analysis method was established to decide the process and quantitative GC analysis method was established to determine the yield of the product.In our study the condition of synthesis such as temperature, time, the status and the ratio of KF to Pentachlorobenzonitrile and the ratio of solvent to Pentachlorobenzonitrile are considered. Under this condition pentafluorobenzonitrile was synthesized. In the same time, the selection of solvents and the preparation of active KF were studied briefly.In the course of study the process of fluoro-hale exchange substitution, the kinetic model is built by the reasonable simplification for the reaction process. The model parameters are determined by useing of Matlab language. Comparing the data of experiment with the value of model, the results was drown that the model can basically fit the process.