A Novel Synthesis Of Biflavone

The reaction of ketone or aldehyde enamines with alkyl halides furnishes alkylated products, while with acid chlorides gives acylated products. Several new flavone's precursor were synthesized by the reaction of 6-chlorosyl-hept-6-enoyl chloride with enamines derived from the acetophenone derivatives, flavones gives by dehydrogenation at the common pressure. A biflavone was synthesized by the reaction of 6-chlorosyl-hept-6-enoyl chloride with enamines derived from the 4,4'-Diacetylbiphenyl, followed by dehydrogenation at the common pressure. The biflavone can be synthesized easily by two steps. It gave an informal route to synthesize biflavone, improved the applied range of stork enamine reaction. This paper possessed high theoretical and latent applied value.