| Batch process is an important production mode in modern industrial production and has been widely applied to a wide variety of fields such as the fine chemical industry, food industry, pharmaceutical and other industries. In recent years, batch process monitoring attracts increasing attention. But the currently theories and methods are difficult to be verified and validated in actual production. Therefore, the design of a batch process simulation system is of great significance to the monitoring theories and applications of batch process.In the batch production process, there is a category related to the fermentation process, such as the production of wine, vinegar, pickles and a variety of dairy products. In this paper, penicillin fermentation is taken as the representative one. After in-depth research and analysis of the penicillin fermentation process, a batch process simulation system is designed based on computer simulation technology.In this design, the mathematical models of an actual production process are established on the basis of the fermentation kinetics. There are four sub-models:cell growth, product synthesis, substrate consumption and dissolved oxygen concentration. The fermentation process factors are temperature, air flow, motor speed, feeding rate, feeding concentration, and etc. Experimental results show that the models can be used to reflect the penicillin fermentation process clearly and accurately.Due to its strong numerical analysis and graphical display features, MATLAB is chosen to solve the differential equations of the fermentation model and show the reaction curves. VC++, which has friendly interactive interface features, is utilized to design the simulation system interface. In the simulation system, by introducing different fault signals to the penicillin fermentation simulation process, the designed system can be used to simulate the real abnormal penicillin fermentation production process clearly. This system extends the fault types that can be introduced. Meanwhile, it can be used to compare and analyze the simulation data of faults and the generated curves in detail. The simulation system of penicillin fermentation process can provide comparison of the validity of different fault detection and diagnosis methods by the data collected from penicillin fermentation simulation, predict the biochemical reaction process, and guide the real production or experiments. Moreover, it can provide an effective research platform for fault diagnosis on batch process. |