The Biochemistry Research Of C-di-GMP Related Proteins In Mycobacterium Tuberculosis

Countless millions of people in the world have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized Mycobacterium tuberculosis strain, H37Rv, has been determined and analysed in order to improve the understanding of the biology of this slow-growing pathogen and to help finding new prophylactic and therapeutic interventions.Bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) has come to the limelight as one of the result of the recent advances in microbial genomics.C-di-GMP is known as a novel global second messenger in bacteria. The GGDEF and EAL domain proteins, which are involved in c-di-GMP synthesis and degradation, respectively, are ubiquitous in bacterial genomes. These proteins affect cell differentiation and multicellular behaviour as well as the interactions between the microorganisms and their eukaryotic hosts.