The Relationship Between Environmental Factors And DBP Gene Polymorphisms With Obesity In Caucasian

Obeisty is one of the most important diseases which areprevalent in whole the world. Studies presented obesity isassociated with the increased risk of other complex diseasessuch as type 2 diabetes (T2D), hypertension, coronary heartdisease and so on. The prevalence of obesity contributes to theoverall burden of human disease worldwide. Since the serioussituation of this disease, it is exigent to find medicines ormethods to prevalence and treatment for obesity.There are two goals of this study: fistly, use body massindex (BMI), body fat mass (BFM), body lean mass (BLM), trunkfat mass (TFM) and percentage of body fat mass (PFM) as thephenotypes of obesity to explore the relationship with someenvironmental factors, such as exercise, sun-exposure, alcohol,tobacco and the input of dairy, make sure if those factors playroles in the development of obesity, on the other hand, detectif there is gender or age specific effect of those environmentalfactors; sencondly, in a relatively large sample of Caucasiannuclear families investigate whether a set of high density SNPsin and around DBP gene is associated with obesity phenotypesincluding BMI, BFM and PFM by using the FBAT software.In caucaisan we found the fat mass is higher in the olderthan the young, while higher in women than in men. And from thestudy of envirment factors we found exercise is an importantdrisk factor of obesity, especially in elderly women. Other environmental factors such as alcohol, tobacco and the imputof dairy play modest role in determination of obesity,interesting, there may be gender or age specific roles of thosefactors. The study of DBP gene in Caucasian nuclear familiesdetect rs17467825 located in the 3' -UTR is asscoted with thevariation of obesity phenotypes, in further studies we observednominal significant association results in female subgroup. Wehypothesize that SNP2 or its highly correlated polymorphismsmay influence the mRNA stability of DBP, since rs17467825 islocated in the 3'-UTR that usually determines the in vivo mRNAdecay rate of a gene. More studies are needed to comfirm thishypothesis.Some useful information and results have obtained from thisstudy. The study on environmental factors of obesity presentsthe effect of those life factors are complex, and maybe relatto gender, age and other factors. The study on the relatiobshipof DBP gene and obesity is based on nuclear families, which isrobust of population stratification. Our studies set up a basisfor the molecular studies of obesity, and are benefit to findeffective medicines or methods to prevalence and treatment forobesity.