Allele And Haplotype Frequency Distribution Of PTEN Related SNP Variation In Southwestern Chinese Han Population And Its Impact On Type 2 Diabetes

Background : Type 2 (non-insulin-dependent) diabetes mellitus is a heterogeneous disease .It has been known that B cell dysfunction and impaired insulin-stimulated glycogen synthesis of the peripheral tissue are the most consistent pathophogenesis characteristics of type 2 diabetes.To further clarify to type 2 diabetes mellitus, we detected and genotyped the gene related with the insulin signaling cassette.Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was originally identified as a candidate tumor suppressor gene. Recently, the protein phosphatase PTEN has been introduced into the insulin signaling cassette as a lipid phosphataes that negatively regulates the concentration of intracellular phosphatidyl-inositol-(3,4,5)-trisphosphate generated in response to the activation of phosphoinositide 3-kinase(PI3K), preventing the downstream phosphatidylinositol(3,4,5) trisphosphate(PIP3)...