Study On The Relationship Between Activation State,Brain Network And Clinical Features Of Migraine Patients At Different Time

Migraine is a common nervous system disease,the pathophysiological mechanism of migraine is unclear,it is generally considered as a disorder of brain function state.The correlation and mechanism between brain function state in different periods and clinical features need to be explored and clarified.The diagnosis of migraine is mainly based on clinical symptoms and differential diagnosis at present.Functional imaging studies have found that migraineurs have increased connectivity in some brain regions of the painprocessing network,but decreased connectivity in pain-regulating circuits.In addition,the limbic system network,default network and executive control network found significant abnormal by resting-state f MRI,suggesting that other symptoms in migraine patients besides pain may also cause changes in the activation and connectivity of brain regions.By combining functional imaging with clinical manifestations of migraine patients in different periods,It is helpful to analyze the relationship between migraine syndrome and brain functional state and activation of brain area in different periods and to understand the pathophysiological mechanism.This study combined neuropsychology,brain functional imaging,functional Magenetic Resonance imaging(f MRI)technology and clinical characteristics of migraine patients to study the connection and state of brain function in different periods of migraine.It provides a new theoretical basis for the pathophysiological mechanism,diagnosis and intervention of migraine.This study mainly includes the following parts:Part one: Study on sleep and mood analysis of migraine patientsConclusion: Migraine patients are prone to sleep disorders,anxiety and depression.Part two:(1)The difference of brain activation in different periods of migraine and its correlation with clinical characteristics by ALFF analysisResults: the episodes group compared with the interictal group,Montreal Neurological Institute(MNI)(19,42,9),the ALFF value of bilateral anterior cingulate cortex was lower than the interictal group(P<0.01),indicating negative activation.Compared with the control group,patients in interictal phase had stronger activation in bilateral anterior cortex,the MNI(12,51,12).Compared with the control group,the MNI(12,51,12)ALFF value of bilateral anterior cingulate cortex in interictal patients was increased(p<0.05),indicating positive activation.There was no significant correlation between clinical indicators and ALFF value.Conclusion: The anterior cingulate cortex plays an important regulatory and adaptive role in the pathogenesis of migraine.(2)The difference of brain activation in different periods of migraine and its correlation with clinical characteristics by Re Ho analysisResult: Compared with the interictal group,patients in the episode group had lower activation in bilateral anterior cingulate cortex(ACC),with Montreal Neurological Institute(MNI)(-9,42,15);and had stronger activation in bilateral paracentral lobule(PCL),with MNI(-3,-24,66).Compared with the control group,patients in interictal phase had lower activation in the bilateral cuneus and bilateral lingual gyrus,with MNI scores of(9,-84,36)and(0,-72,6),respectively.In the episodes group,a significant correlation was observed between attack frequency and Re Ho value of the bilateral PCL(r=0.492;P=0.038).Conclusion: The functional status of brain area is different between migraine episode period and interictal period.The activation of the wedge and lingual gyrus was lower in the interictal period than in the control group,suggesting that the visual cortex damage was persistent.ACC is one of the key brain regions,The paracentric lobule is not only associated with migraine attacks,but also with the frequency.This may have an effect on the outcome of subsequent migraines,as well as whether the condition becomes chronic,and the remodeling of the brain.(3)The connection between the brain regions of interest and other brain regions in different periods of migraine based on seed point analysis method.Based on prior knowledge,thalamus and insula were selected as regions of interest.The functional network connection of the left thalamus and bilateral caudate nucleus was different between the episode group and the control group,and the functional connection of the above regions were enhanced in the episode group(P < 0.05).The functional network connections of the right thalamus,bilateral insula and bilateral torque gyrus were different between the episode period and interictal period,the functional connections of the above brain areas were enhanced in the episode group(P < 0.05).The functional network connections of the right thalamus and left caudate nucleus were different between the interictal group and the control group,the functional connections of the above areas were enhanced in the interictal group(P < 0.05),but the results were not corrected by GRF.Conclusion: The thalamus,caudate nucleus,insula and torque gyrus may be the key brain regions of migraine,but they are not corrected by GRF.There was a trend but no statistical significance.Part three: The changes and significance of brain networks in migraine patients at different periods by Independent component analysis(ICA)Result: Matrix analysis of 26 meaningful branches in the interictal group and the episode group,found Dorsal Attention-Default 、 Dorsal Attention-Somatomotor 、Frontoparietal-Dorsal Attention、Frontoparietal-Somatomotor、Limbic-Dorsal Attention、Limbic-Ventral 、 Limbic-Somatomotor 、 Ventral-Somatomotor 、 Default-Default 、Somatomotor-Dorsal Attention have significant difference(P<0.05).It was more significant in Frontoparietal,Somatomotor、Dorsal Attention 、Limbic and Default(P < 0.01).Conclusion: The brain function connectivity has significant differences between episode group and interictal group with migraine,which are mainly reflected in in Frontoparietal,Somatomotor 、 Dorsal Attention 、 Limbic and Default network(P < 0.01).Each network interact with each other.