Research On The Integration And Application Of Flexible Multimode Self-decoupling Diagnostic And Treatment Electronic Devices

Major chronic diseases are characterized by multiple parameters,time variability and degenerative characteristics,which typically cannot be timely detected through annual routine check-ups.To achieve early diagnosis and interventionist treatments,it is necessary to conduct long-term sensing and monitoring analysis of relevant physiological parameters to prevent disease progression and exacerbation,thus reducing the complexity and difficulty of subsequent treatments.Stretchable and flexible diagnostic and therapeutic electronic devices can conformably adhere to the human body,enabling precise sensing of physiological signals and stimulation intervention for major diseases,safeguarding public health,and enhancing the efficiency of healthcare resource utilization.These devices are evolving towards multifunctionality,integration,and intelligence.The key challenge lies in developing diagnostic and therapeutic electronic devices with multiple types of functional units integrated in a stretchable and flexible system.This paper focuses on the core issue of"flexible functional integration"and primarily conducts two main works.On one hand,the multi-physics fusion sensing technology with complex structural mechanics modulus matching was proposed,and the multimodal self-decoupling sensitive response model for multi-degree-of-freedom tissue organs was established to realize low cross-sensitivity and no crosstalk sensing between physical and biochemical mixed signals.On the other hand,a retinal health management model associated with sensing parameters and intervention modes for precise diagnosis and treatment of retinal damage was developed.The specific work is as follows:（1）To address the challenge of precise detection of biochemically substances in bodily fluids under complex temperature environments,a novel approach has been developed based on the multi-potential sensing mechanism,enabling multimodal self-decoupled analysis of sweat components.This approach involves the design and fabrication of a biomarker recognition unit using Co₃O₄ nanowire/carbon cloth fibers.Through exploiting the differential oxidation peak positions in electrochemical reactions（dopamine～0.2 V,lactate～1.1 V）,specific differentiation of biomarkers is achieved.A flexible dopamine/lactic acid sensing skin patch with temperature calibration function was constructed by integrating the biomarker recognition unit and a serpentine-structured temperature calibration unit,and based on mechanical modulus matching stackable integration scheme.The overall size of the patch is 3×2×0.06 cm³,exhibiting excellent extensibility（>40%）,a broad electrochemical detection linear range（dopamine:0.001-1.100 m M,lactate:2-35 m M）,as well as high selectivity and reproducibility（with errors of 3.2%for dopamine and 5.6%for lactate）.Combined with wireless micro-electrochemical test system,real-time analysis and monitoring of sweat composition under temperature calibration is realized.（2）To address the collaborative sensing of multiple physical fields under space constraint conditions,a novel multimodal self-decoupled ocular multi-signal sensing method based on modifiedγ-Fe₂O₃ material was developed to design and prepareγ-Fe₂O₃@Ni O magnetic oxide nanosheet sensitive material.These units enable monitoring of fluctuations in intraocular pressure(sensitivity:0.17 MHz mm Hg^-1)and eye movement（accuracy>95%）through shifts in electromagnetic induction characteristic frequencies and variations in magnetic field intensity.This unit can also achieve electrochemical response to tear glucose（detection limit:0.43μM,linear range:0.005-6.0m M）by improving chemical activity through Ni O modification.Further incorporated mechanical-electromagnetics collaborative optimization design and conformal integration strategies to construct a contact lens capable of concurrently monitoring intraocular pressure,eye movement,and tear glucose levels.The contact lens can be combined with frame glasses with information acquisition function to realize non-interfering sensing of both chemical and physical signals in the eye,and can be used for long-term dynamic monitoring,which is expected to avoid the malignant development of chronic eye diseases and increase the difficulty of treatment.（3）To address the precision diagnosis and treatment needs for retinal injury,models of primary and secondary retinal damage induced by optic nerve injury and diabetes have been established.An ocular health diagnostic and therapeutic contact lens with functions of tear glucose monitoring,electroretinogram monitoring and wireless near-red phototherapy functionality was designed.Employing a visual paper-based glucose sensing strategy utilizing Fe₃O₄/graphene oxide composites,the device exhibits a wide detection range（0.01-11 m M）and high linearity（R²=0.9846）in response to tear glucose levels.The integrated flexible film bioelectrodes further combine with external testing systems to accurately capture and record key indicators representing retinal functional status（a-wave and b-wave）.Incorporating inductive coupled wireless energy transmission and micro NIR light-emitting diodes,the device administers NIR light therapy to modulate the secretion behavior of neurotrophic factors and inflammatory cytokines,thereby treating retinal injury.This device for multimodal sensing and therapy in both primary and secondary retinal injuries have been studied,successfully achieving remote monitoring and treatment of retinal damage.This innovation aids in alleviating therapeutic challenges and reducing the risk of blindness associated with the exacerbation of ocular diseases.