Basic Research On Dynamic Bonded Self-healing Binder Construction And Its Application In ECMs

The micro surface morphology has a crucial and important impact on the biocompatibility of implants.Micro-nano textured surfaces can exhibit superior biocompatibility,providing a new direction for the development of implants.With the aging of the population both at home and abroad,there is an increasing demand for implants both at home and abroad,and Ti-Ta alloy,as a high-quality material for human bone implants,has been gradually applied in the field of clinical medicine.However,the binding between Ti-Ta alloy implants and surrounding osteoblasts remains an urgent issue that needs to be addressed.Therefore,researchers are working on surface modification of Ti-Ta alloy implants to improve their biocompatibility and better serve patients.Ultrasonic cavitation and micro abrasive particles synergistically impact the surface of Ti-Ta alloys to form micro-nano-structures,which are favorable for binding with surrounding osteoblasts,thus improving the biocompatibility of Ti-Ta alloy implants;however,there is always a lack of complete and comprehensive theoretical and experimental studies on the development and validation of the micro-nano texture of the surface of Ti-Ta alloy.In order to explore the biocompatibility of Ti-Ta alloy micro-nano textured surfaces synergistic processed by ultrasonic cavitation and micro abrasive particles,this paper is based on bubble dynamics and constructs theoretical models such as velocity pressure model and impact load model for ultrasonic cavitation and micro abrasive particle synergistic impact on Ti-Ta alloy.Furthermore,the effects of ultrasonic field and non dimensionless（R/R₀）cavitation bubble collapse are simulated and analyzed.Ti-Ta alloy with micro-nano textured surfaces is obtained through experimental processing,and its biocompatibility is evaluated using cell culture experiments.Finally,a comprehensive paper framework of"theory and model and simulation and experiment and verification"is formed,which comprehensively explores the biocompatibility of ultrasonic cavitation and micro abrasive particles synergistically impacting the micro-nano textured surfaces of Ti-Ta alloy.The main research content carried out is as follows:（1）Studied the synergistic mechanism of ultrasonic cavitation and micro abrasive particles.Starting from ultrasonic vibration machining,this paper studies the equipment of ultrasonic vibration machining system,analyzes the principle of ultrasonic vibration machining,compares various bubble dynamics models and mechanisms,and theoretically elucidates the principle of synergistic effect between ultrasonic cavitation effect and micro abrasive particles.In addition,based on the dynamics of cavitation bubbles,a continuous control equation was established for shock waves,micro jets,and micro abrasives to be uniformly affected by the dimensionless collapse of cavitation bubbles（R/R₀）,and the three were integrated for research;Furthermore,establish a velocity pressure model for ultrasonic cavitation and a particle size velocity pressure model for ultrasonic cavitation induced micro abrasives;Finally,establish a model for the impact load of ultrasonic cavitation effect and micro abrasive particles on the surface of Ti-Ta alloy.A comprehensive numerical theoretical model for the entire process of synergistic impact of ultrasonic cavitation and micro abrasive particles on Ti-Ta alloy has been constructed,providing a numerical theoretical basis for the synergistic impact of ultrasonic cavitation and micro abrasive particles on Ti-Ta alloy.（3）The impact load and pressure caused by ultrasonic cavitation and micro abrasive impact induced by ultrasonic cavitation on the surface of Ti-Ta alloy were inverted and analyzed,verifying the correctness of the ultrasonic cavitation and micro abrasive pressure models.Based on the experimentally obtained parameters of ultrasonic cavitation and micro abrasive erosion pits,the impact loads of ultrasonic cavitation and micro abrasive particles on the surface of Ti-Ta alloy were inverted and analyzed.Then,the inversion and simulation results of ultrasonic cavitation and micro abrasive particle pressure were compared.By combining simulation and experiment,the inversion and comparative analysis showed that the error rate of ultrasonic cavitation pressure was 1.751%,and the error rate of micro abrasive particle pressure was 8.769%,confirming the correctness of the overall mathematical model of ultrasonic cavitation and micro abrasive particles.In addition,the establishment of the fitting equation provides a new theoretical model for calculating the impact load of ultrasonic cavitation and micro abrasive particles on the surface of Ti-Ta alloy.（4）The morphological characteristics of Ti-Ta alloy under ultrasonic cavitation and micro abrasive impact with different particle sizes and mass fractions were experimentally studied.The experimental results show that the erosion pits of Ti-Ta alloy under ultrasonic cavitation impact are black,resulting in surface material removal and peeling,and the shape contour is irregular with burrs;The erosion pits caused by spherical smooth micro abrasive impact on Ti-Ta alloy maintain the original surface color,without causing material removal and peeling,and the overall shape is bowl shaped.In terms of surface morphology,the ultrasonic cavitation erosion pits on the surface of Ti-Ta alloy increase the risk of particle detachment and entry into the bloodstream.Therefore,the biocompatibility of Ti-Ta alloy under ultrasonic cavitation impact is not as good as that under micro abrasive impact.Through characterization results,it was found that the impact of spherical smooth micro abrasive particles with different particle sizes on Ti-Ta alloy mainly affects the diameter and depth of erosion pits.The larger the particle size,the larger the diameter and depth of erosion pits;The impact of spherical smooth micro abrasive particles with different mass fractions on Ti-Ta alloy mainly affects the number of erosion pits.In addition,in terms of micro abrasive particle size,compared with corresponding literature,it was found that 10μm.the roughness,surface morphology,and erosion pit parameters obtained by micro abrasive erosion of Ti-Ta alloy are more conducive to the biocompatibility of micro-nano texture on the surface of Ti-Ta alloy,but the appropriate mass fraction cannot be determined through impact testing.（5）We designed and conducted cell culture experiments to verify the cell compatibility of Ti-Ta alloy micro-nano texture surfaces,and optimized the selection of micro abrasive particle size and mass fraction during the processing.Firstly,cell culture experiments were conducted on the surface of Ti-Ta alloys processed by micro abrasive particles of different sizes.The biocompatibility of Ti-Ta alloys eroded by different particle sizes was determined by macroscopic changes after surface cell staining and absorbance data detection.The Ti-Ta alloy eroded by 10μm spherical smooth Si O₂ micro abrasive particles had the best biocompatibility;Subsequently,cell culture experiments were conducted on the surface of Ti-Ta alloy with 2 wt%,4 wt%,and 8 wt%10μm micro abrasive particles.The macroscopic changes after surface cell staining and absorbance data were also detected to verify the adsorption and proliferation of cells on the surface of Ti-Ta alloy,in order to determine the biocompatibility of spherical smooth Si O₂ micro abrasives with different mass fractions on Ti-Ta alloy.The final results showed that the Ti-Ta alloy micro-nano textured surface treated with 8 wt%10μm spherical smooth Si O₂ micro abrasive particles showed a 94.561%increase in cell adsorption and proliferation compared to the untreated Ti-Ta alloy surface.Therefore,in comparison,the Ti-Ta alloy micro-nano texture surface treated with 8 wt%10μm spherical smooth Si O₂ micro abrasive particles can exhibit better biocompatibility,fully proving that the micro-nano texture obtained by the synergistic effect of ultrasonic cavitation and micro abrasive particles in Ti-Ta alloy effectively improves biocompatibility.