Professor Teo Eng Kiat's Experience In Differentiating And Treating Non-small Cell Lung Cancer (NSCLC)

ObjectiveThis paper is to study and summarize Professor Teo Eng Kiat's academic thought and years of clinical experience in treating of non-small cell lung cancer(NSCLC).Based on Professor Teo Eng Kiat's solid foundation in clinical practice,this research is to excavate Professor Teo Eng Kiat's unique method of differentiating and treating of non-small cell lung cancer(NSCLC),so as to guide future scholar through"combination of diseases and syndromes",using specific prescription to treat every different stage of the disease,in the field of traditional Chinese medicine.Method1.Theoretical research section1.1.Collation of relevant Chinese medicine's literature records of non-small cell lung cancer written by the sages of ancient medicine and famous doctors of different dynasties.Mainly organizes the related disease's names,etiology,pathogenesis,syndrome differentiation,treatment's principle,prescription and herb used.1.2.Retrieve and summarize the recent research reports of non-small cell lung cancer in the past ten years and integrate different research advances.1.3.Summarize the unique insights of Professor Teo Eng Kiat on non-small cell lung cancer.Mainly summarizes on the different views on the Chinese medicine etiology,pathogenesis,syndrome differentiation and treatment principle of non-small cell lung cancer.2.Clinical research section2.1.Collect,organise,and analyse all cases of non-small cell lung cancer diagnosed and treated by Professor Teo Eng Kiat in the past fifteen years,based on the three years of mentoring by Professor Teo Eng Kiat.Summarise Professor Teo Eng Kiat's experience and unique method of treating non-small cell lung cancer while collating 85 cases of his of non-small cell lung cancer patients' records.2.2.Summarise the main types of syndrome differentiation,prescription and herbs used by Professor Teo Eng Kiat in treatment of non-small cell lung cancer,as well as his clinical experience in treating various clinical symptoms such as cough,hemoptysis,rash and constipation etc.Explore and analyse of how Professor Teo Eng Kiat uses the characteristics and advantages of Chinese medicine to grasp the overall situation from overview to locally,"combination of disease and syndrome" and macro to micro aspects.2.3.Using traditional Chinese medicine inherit support platform software to compile,statistical,analyse,and summarised all the non-small cell lung cancer patients' medical records who was treated by Professor Teo Eng Kiat for the past 15 years.This analysis focuses on the distribution of the following properties:the patient's gender,age and frequency of symptoms,common syndrome,prescriptions,herbs usage,prescriptions,herb pairs,herb categorisation of four qi,five flavours and meridians distribution.2.3.All the medical records of the non-small cell lung cancer patients diagnosed and treated by Professor Teo Eng Kiat during the past 15 years are analysed by using the traditional Chinese medicine inheritance assistant platform software to carry out statistical analysis,and then summarize the data used for mining,analysis and discussion.Using these medical records,the research observe mainly on gender and age,the incidence of a variety of different symptoms,common symptoms,common used prescriptions,common used herb pairs,the distribution of the four qi,five flavours,and meridians distribution of all herbs and the frequency of herbs used.3.Discussion sectionBy observing the collected medical records,the results of data mining,together with three-year theoretical collation of mentor experience,and then combined Professor Teo Eng Kiat treatment experience to make a corresponding summary.Discuss Professor Teo Eng Kiat herb usage pattern in treatment of non-small cell lung cancer,and propose commonly seen symptoms,syndromes,prescriptions and herbs used,to guide future scholar in different prescription method in the field of Chinese medicine,benefiting every patient.Result1.Discussion of Professor Teo Eng Kiat's understanding in non-small cell lung cancer pathological evolution process,as the etiology and pathogenesis are mainly due to deficiency of spleen qi,while cancer toxicity,phlegm,blood stasis and heat are secondary causes.These secondary causes will interact with one and another to form a physical mass as a malignant tumour,seizing the patient's essence,harming their health.However,the disease will occur,only when low immunity unable to protect ones against the cancer toxicity.2.Describe in detail how Professor Teo Eng Kiat distinguishes and treats various common symptoms and complications of non-small cell lung cancer clinically.Such example are cough,hemoptysis,rash and constipation,etc.and discussed Professor Teo Eng Kiat dialectical thoughts and herbal formula usage experience on treating these symptoms.3.Analysis of medical records and medications:There were 85 patients who met the standards,42 were males,accounting for 49.41%of the total number of cases,and 43 were females,accounting for 50.59%of the total number of cases.The age is about 29-92,and the average age is about 66.41 years.There were 314 clinical symptoms in 85 patients;the total herbs were 182 kind.The main category of herbs used are herbs that can be used for replenish qi,heat clearing,detoxifying,warming,blood circulation,clear blood stasis,reduce phlegm and nodule;Warm herbs are the main type,followed by cold herbs,the sweet flavour is the most common,accounting for 37.28%,the bitter flavour is 33.43%.The spleen meridian is the most common,which accounts for 24.59%and secondly,the lung meridian accounted for 22.99%.Conclusion"Deficiency of spleen qi and stagnation of phlegm,heat,blood stasis,toxicity" are the pathogenesis of non-small cell lung cancer,while deficiency of spleen qi is the prerequisite for the onset of the disease and could be found throughout all the stages of the disease.Cancer toxicity is a key element in the etiology and pathogenesis of non-small cell lung cancer,while phlegm and blood stasis are an additional condition for the formation of cancer toxicity.In terms of treatment,using various treatment principle,treatment of the spleen and lungs simultaneously,and using of both clearing and nourishing method.Based on the clinical characteristics of the lung cancer,a treatment principle based on "nourishing spleen,clearing lung" was established,and special nourishing spleen,clearing lung decoction was designed for the treatment.This reflect Professor Teo Eng Kiat's unique experience and insights in treating non-small cell lung cancer.In terms of medical records and herbal formula analysis,for symptoms,fatigue and cough are the most common symptoms.Dark red tongue and thin pulse are the most common signs for tongue and pulse diagnosis.In term of overall herbal formulation,nourishing of spleen and lungs,removing phlegm and nodule,clearing heat and detoxifying,promoting blood circulation,removing blood stasis are the basic core principle of prescriptions;the overall herbal efficacy shows that the main focus are nourishing qi,warming body,clearing heat,detoxifying and removing phlegm and nodule.