Study On Mild Cognitive Impairment's Literature Of Traditional Chinese Medicine And Clinical Observation On The Effect Of Zhangzhi Shengbai Powder On MCI

Objectivein the past 15 years,to summarize the rule of syndrome differentiation and treatment,and to discuss the theoretical basis of Zhangzhi Shengbai Decoction from the relevant laws of"drug-syndrome";to design clinical trials,The efficacy and safety of the patients with MCI in the treatment of spleen and kidney deficiency and blood stasis syndrome were investigated by the method of Zhangzhi Shengbai powder,which was effective in treating and recovering the encephalopathy.Lay the foundation for the promotion and application of treatment.MethodChinese Journal of Traditional Chinese Medicine.Chinese Journal of Integrative Medicine on Cardio/Cerebrovascular Disease].Chinese Journal of Integrative Medicine on Cardio/Cerebrovascular Disease].According to the serial number,dialectical classification,treatment,Chinese medicine name,prescription name,etc.,followed by entry Excel 2010 software,generate the total database,and then export four sub-database,followed by the frequency of statistics,according to the statistics,And the correlation analysis method was used to analyze the clinical manifestations,syndromes,syndromes,frequency of traditional Chinese medicine,prescriptions and syndromes of MCI.Combined with the results of the database analysis,60 patients who met the study were randomly divided into treatment group and control group.The control group was acupuncture at the acupoints of the acupoints.The treatment group was treated with oral Zhangzhi shengbai powder for 8 weeks and followed up for 3 months.The cognitive function of the two groups was evaluated before and after treatment.Ability,TCM syndrome score and the incidence of adverse reactions.ResultPART 11.According to the inclusion and exclusion criteria,229 literatures,including 115 drugs,the total frequency of drug use was 4231,and 382 prescriptions were included.There were 382 prescriptions of Chinese medicine,among which there were square names,which could inquire about the origin of MCI.Prescription 98,prescription use a total of 863 times the frequency;which contains 63 symptoms,the symptoms of the total frequency of 2391 times;syndrome appeared 35,syndrome name using the total frequency of 373 times.Resolution frequency of the syndrome,the total frequency of the syndromes is 532,the total frequency of the two syndromes is 315,the total frequency of the three prime is 107.2.The frequency of more than 80 times the total of 30 kinds of drugs,followed by ginseng(161 times),Sm(153 frequency),epimedium,Radix Rehmanniae(142 frequency)(137 frequency),Millettia(134 frequency),Chrysanthemum(142 frequency),Rehmannia(137 frequency),Millettia(134 frequency),Astragalus(132 frequency),Salvia miltiorrhiza(132 frequency)(682 frequency),antipyretic drugs(643 frequency),sputum drugs(553 frequency),qi drug(429 frequency),open surgery drugs(373 frequency),these drugs are tonic drugs(950 frequency),blood circulation drugs(682 frequency),Which tonic drugs are mainly American ginseng,Epimedium,Rehmannia,Astragalus,Ginseng,Yizhi Ren;blood circulation drugs use the higher frequency of Salvia,Millettia,Chuanxiong,Sanqi,peach kernel,turmericThe Commonly used drugs four gas is the temperature(89 frequency),micro temperature(74 frequency),flat(65 frequency),heat and cool less;flavors in the Xin(93 frequency),Gan(89 frequency)(39 frequency),followed by astringent(39 frequency),light(34 frequency),acid(12 frequency),salty(6 frequency),supplemented by3.Commonly used prescription is:Dingzhi pills(144 frequency),Liu Wei Di Huang Wan(122 frequency),Angelica Shaoyao San(106 frequency),far Chi San(98 frequency),fresh Kaiqiao side(87 frequency)77 frequency).4.Common symptoms are fatigue(179 frequency),tinnitus(165 frequency),aversion to cold(132 frequency),nocturia frequency(121 frequency),looking Shaohua(113 frequency),Yaoxisuanruan(104 Frequency),the rest of the frequency of more than 10 times the symptoms of 30,and the frequency of more than 10 times a total of 8,from high to low,respectively,kidney yin deficiency syndrome(72 frequency),blood stasis brain syndrome(63 frequency)(Frequency),spleen and kidney yang deficiency syndrome(42 frequency),heart and spleen deficiency syndrome(36 frequency),kidney yin deficiency syndrome(33 frequency),spleen deficiency syndrome(18 frequency),liver and kidney deficiency syndrome(12 frequency)11 frequency).5.The frequency of more than 5 times the evidence of 15,accounting for 94.7%of the total frequency of evidence,the first six were kidney(88 frequency),blood stasis(75 frequency),spleen(64 frequency),Yin),Phlegm(43 frequency),yang(38 frequency);frequency ? 5 times the combination of the two syndromes have 10,accounting for the total number of two combinations of syndromes 94.3%,the first six were kidney deficiency+(37 frequency),blood stasis+qi stagnation(29 frequency),qi deficiency+kidney deficiency(21 frequency),qi deficiency+blood stasis(52 frequency),spleen deficiency+kidney deficiency(42 frequency)Three syndrome frequency?10 frequency of 5,accounting for 84.1%of the total frequency,mainly qi deficiency+kidney deficiency+blood stasis syndrome(28 frequency),Yin+spleen+kidney deficiency syndrome(23 frequency),marrow deficiency+Yin(17 frequency),qi deficiency+yang deficiency+phlegm syndrome(12 frequency),marrow deficiency+fine deficiency+blood stasis syndrome(10 frequency).6.The correlation analysis shows that,clinical use of more drug compatibility is Salvia and Rehmannia(28.0%),Western participation in Salvia(25.2%),Radix Salviae Miltiorrhizae(24.8%),Astragalus and Epimedium(23.8%),Salvia miltiorrhiza(24.8%),Salix psammophila),People participate in Salvia miltiorrhiza(23.1%),Chuanxiong and Salvia miltiorrhiza(22.5%).7.In the treatment of kidney yin deficiency syndrome of commonly used drugs(support>10%)is(16.7%),Salvia miltiorrhiza and Radix rehmannia and Radix Astragali and radix astragali(15.9%)and(15.2%),Lily(14.8%),American ginseng and Salvia Chuanxiong and Radix Salviae Miltiorrhizae,Rhizoma Chuanxiong and radix astragali(14.3%)(13.6%);drug and blood stasis in brain "drug-card match(support>10%)are(15.3%),Salvia miltiorrhiza and Millettia Chuanxiong and Radix Astragali,radix astragali(14.5%)and(14.2%),(13.4%),Radix Salviae Miltiorrhizae and Radix Angelicae Sinensis and Radix Paeoniae Alba,Rhizoma Chuanxiong and radix rehmanniae(13.1%),Radix Rehmanniae Preparata and Rhizoma Chuanxiong(12.8%).PART 21.Compared with before treatment,the treatment group and the control group in the overall efficacy analysis,Ridit analysis,TCM syndrome curative effect Ridit MMSE total score and each dimension score,graphics recognition,measurement of integral aspects,there are significant differences,with statistical significance(P<0.05).2.Compared with the control group,the overall efficacy analysis,Ridit analysis,the efficacy of TCM syndrome total score of MMSE and Ridit graphics recognition,measurement of integral aspects,there are significant differences,with statistical significance(P<0.05);compared with the control group,the treatment group improved significantly in memory,language,application and judgment 4,the difference was statistically significant(P<0.05);and the two group in the improvement of visual spatial skills,computing ability scores,no significant difference between the two effects(P>0.05).3.After treatment at the end of the follow-up of 4 weeks,compared with the control group,the treatment group in the overall efficacy of Ridit analysis,MMSE total score and graphical recognition of the integration of statistical differences,and has statistical significance(P<0.05).During clinical observation,the two groups in the blood,urine,fecal routine and liver and kidney function and other routine physical examination items,were not found abnormal.Conclusion1.Nearly 15 years of traditional Chinese medicine treatment of mild cognitive dysfunction,mainly that the disease to kidney yin deficiency,blood stasis brain syndrome more common around the "spleen,kidney,heart,liver" and other dirty,from the " Blood stasis,sputum "and other aspects of dialectical,to determine the" tonic,Tongluo,expectorant,blood circulation "and other treatment,clinical selection of drugs to tonic drugs,blood circulation drugs,Qi drug compatibility prescription.Can be considered "Spleen Yishen,blood circulation,wake God puzzle" is a mild cognitive function of one of the main law.2.In line with Traditional Chinese medicine treatment of mild cognitive dysfunction"drug-card" law of Zhangzhi Sheng bai powder,is the clinical manifestation of "Spleen Yishen,blood circulation,wake God puzzle" In the treatment of spleen and kidney deficiency,blood stasis brain network card mild cognitive dysfunction was significant.This side can improve the clinical manifestations of patients,TCM syndrome efficacy,cognitive function and short-term memory function score,especially in improving memory,language,use,judgment and so on,the effect is significant.4 weeks follow-up results show that the MMSE score and short-term memory function,the party is still valid.No side effects were observed during clinical observation.