Study On Brain Mechanism Of Spatial Volume Perception And Sensory Memory Using Finger Touch

In the last few years,with development of science and technology,brain science has been a significant domain around the world.Human brain cognition obtains information from the external world through five sensory organs: sight,hearing,touch,taste and smell.Recently,the understanding of human brain mechanisms of tactile mechanism is limited as the tip of an iceberg.Because of the limitations of tactile mechanism device,the study on the tactile brain mechanisms is less backward than the visual,auditory brain mechanisms.The brain mechanism of tactile mechanism is difficult and challenging,thus the study of tactile mechanism has been a frontier scientific problem which has interdisciplinary and comprehensive characteristics.As the saying goes,“fingers connected with your heart”,the human fingers are the most sensitive tactile sensory organ,and the most familiar connected with the brain.This topic,is based on the mechanism of haptic volume tactile perception by finger,which combine with electroencephalograph and functional magnetic resonance imaging of the multimodal brain information processing technology.Our lab overcome the difficulties of high resolution nuclear magnetic compatibility finger tactile stimulation device development,and uncover finger tactile mismatch negative wave and the brain mechanism of sensory memory to provide theoretical basis and technical support for super early diagnosis for Alzheimer' s disease.The main content is summarized as follows:Firstly,from antecedent study on spatial volume perception of palm touch,this research employ the weighted cumulative Gaussian distribution function which can cumulate volume of the solution space and distinguish threshold volume.This research uncover fingers tactile perception and combine with the physical structure of finger anatomy to build a finger tactile perception behavior model.Then,to find the precise fingers tactile perception theory;the fundamental characteristics and laws of control strategy.It prove that the distal knuckle of the index finger is the most sensitive part of the finger's tactile perception,and to lay a theoretical foundation for the subsequent research on the mechanism of finger's tactile brain and the super-early diagnosis of Alzheimer's disease.Secondly,this research develop a tour finger to stimulate the brain electrical experimental paradigm which is based on finger tactile perception behavior model and study the fingers tactile mismatch negative wave of brain electrical mechanism through time,frequency and complex brain network of EEG analysis method.It reveals the central frontal cerebral cortex area in the theta frequency mismatch fingers touch the core role of negative wave adjustment,as well as the whole brain cortex theta and gamma spectrum information flows to the fingers touch the synergy effect in the process of mismatch occurred.From above,a new,reliable and efficient method for the extraction of the electrical signature signal of finger tactile mismatch negative wave which supplement the future research of mismatched negative wave in various sensory channels is proposed.Thirdly,this research adopt pneumatic feedback control and precision machining of micro mechanism of magnetic technology;solve the difficulties in preventing magnetic high magnetic field measurement environment;develop tour fingers nuclear magnetic stimulation paradigm;explore finger tactile perception memory brain mechanisms.It is found that the somatosensory cortex,the insular cortex and the prefrontal cortex are the core brain areas that regulate the tactile sensory memory of fingers.Then,from the above result,it is speculated that the occurrence of sensory memory is actually a kind of attention conversion process.It is very important in enriching and improving the research on the mechanism of sensory memory brain,and providing a new way for the super early diagnosis of senile dementia and other brain neurological diseases.Finally,this research has been employed to the clinical diagnosis of Alzheimer's disease.The finger tactile perception behavior and sensory memory accurate measurement and classification of brain function signal can not only reveal the cognitive aging brain mechanisms,but also facilitate to explore the subjective cognitive decline in biomarker and super early diagnosis of Alzheimer' s disease.It is expected to slow conversion of part of the older population with dementia tendency to speed of the dementia or maintain their normal cognitive level;greatly improve quality of life of older population;greatly save a lot of medical and nursing costs;powerfully build national pension security system construction.This paper focuses on finger tactile perception and brain mechanism,and conducts systematic and multidimensional studies on cognitive behavior,electroencephalograph,neuroimaging and other levels.Research results of this thesis has important contribution to know normally fingers tactile perception and brain mechanism.In addition,the research will greatly promote the development of brain science in super early diagnosis and cranial nerve disease which is based on the finger tactile perception function decline of cognitive model of Alzheimer's disease.