Research On The Control System Of 3D Bio Printing Device For The Artificial Vascular Endothelialization

Due to the prevalence of exposure to risk factors of cardiovascular disease,the number of deaths is on the increase.In order to achieve the 3D bio printing technology in clinical application of cardiovascular diseases as soon as possible,in recent years,3D bio-printing device for artificial endothelialization of vascular development work has attracted great attention of researchers.With the support of the National 863 project,the research object of this paper is the control system of 3D biological printing device based on artificial vascular endothelialization,and mainly including the research targets,device control scheme,system composition,motion control algorithm,temperature control algorithm and human-machine interface and so on.The research work and the main innovations are as follows.(1)Through research the vascular tissue printing technology and rapid prototyping technology,and to put forward the 3D bio printing device for artificial endothelialization by double nozzle six axis interpolation movement of the print program and 3D rotary forming rapid prototyping program.(2)According to the composition of the device and the system control scheme,focusing on the various subsystems of hardware and software.The hardware part includes the main controller,motion control system,direct control system and temperature control system of semiconductor assembly process pressure;the software includes TwinCAT software,the work flow of the main controller,the linear motor reference back zero programming and man-machine interface software.(3)The PID control algorithm of the CX2030-0123 controller in suppressing the limitations of linear motor tracking error volatility on the X axis,the sliding mode control technique is proposed.The adaptive Matlab/Simulink simulation experiments by 3D bio printing device X axis linear motor servo system of printing experiment and ASMC controller and PID control algorithm,the experimental results show that the application of in CX2030-0123 controller ASMC control algorithm can make the position error plus or minus 1?m of X axis was significantly reduced,and the control algorithm of ASMC thrusts fluctuation of X axis plays significant inhibitory effect.(4)According to the temperature fluctuations and overshoot in the temperature control system test,in order to improve the temperature control precision and reduce overshoot,the temperature self-tuning fuzzy PID control algorithm is proposed for the temperature control system.Through the simulation and experimental results show that the heat transfer process of heat induced in the semiconductor refrigeration directly,fuzzy self tuning control precision temperature control PID control algorithm of temperature control system in the range of plus or minus 0.5? and can effectively inhibit or reduce the temperature fluctuation and nonlinear system overshoot,greatly improve the temperature control the quality of semiconductor refrigeration and heating.It is beneficial to meet the strict requirement of the quality and activity of biological tissue rapid prototyping for the 3D biological printing device temperature control system of the 3D bio printing device for the artificial vascular endothelialization.(5)There are the printing continuity and the forming quality of the two experiment indexes,3D bio printing device using self-developed nano field experiments and gelatin mixture of biological brick and seaweed acid,the best parameters to get a print material rapid forming set interval,realizes the rapid prototyping 3D bio-printed,provides reference data 3D bio printing.The experimental results verify the correctness and reliability for the control system of the 3D bio printing device.