| he prenatal toxicity of petroleum creosote, a complex mixture of chemicals, was investigated via an in vivo study and an in vitro embryo culture system. Additionally, the prenatal toxicity of naphthalene, one chemical component of petroleum creosote, was determined in the in vitro system. The purpose of the study was to provide specific data on the prenatal toxicity of petroleum creosote and demonstrate the value of the two techniques. In the in vivo study, petroleum creosote was not embryotoxic or teratogenic in ICR mice when administered on gestation days 5-9, at a dose of 400 mg/kg body weight. In vitro, petroleum creosote becomes embryotoxic to ICR mouse blastocysts at some exposure level between 22 and 33... |
