ver-stimulation of N-methyl- scD-aspartate (NMDA) receptors is thought to mediate the calcium-dependent neurotoxicity associated with hypoxic-ischemic brain injury, epilepsy, and several neurodegenerative diseases. Therefore, various NMDA antagonists have been investigated for their therapeutic potential in these diseases but none has proven to be both effective and safe. In whole-cell recordings of rat retinal ganglion cells at... |