| oss of capillary barrier integrity can lead to uncontrolled shifts of fluid and proteins from the vasculature. To distinguish mechanisms underlying increases in transcapillary water and solute flux, changes in capillary permeability were examined under two different experimental conditions known to increase in transcapillary water and solute flux. One condition increased capillary permeability by altering protein content of solutions to which the capillary was exposed. The second condition involved the use of selected natriuretic peptides, one of which was known to increase transcapillary water flux. All measurements were made in situ in single perfused frog (Rana pipiens) mesenteric capillaries. Capillary hydraulic conductivity (;Three hypotheses were tested: (1) hydraulic conductivity is increased by natriuretic peptides found in frogs and humans. Specifically, human brain natriuretic peptide (BNP) and frog and human C-type natriuretic peptide (CNP); (2) frog atrial natriuretic peptide (fANP) increases... |
