Structural and functional determinants for the retention of T-cell antigen receptor alpha chain variants within the endoplasmic reticulum

A central tenet in cell biology is that abnormal secretory proteins, which are misfolded and incompletely assembled are retained intracellularly within the endoplasmic reticulum (ER). Two variants of the T-cell antigen receptor ;Furthermore, data is presented which suggests that a discrete peptide sequence within the extracellular domain of the TCR-...