| Data of this study indicate that in rats, the rectal route was equally effective as the oral route for delivering ddI. The rectal bioavailability averaged 15.6 ;Antitumor activity and systemic toxicity of were compared following rectally and orally administered 5;Intestinal toxicity was also investigated at the cellular level using rat intestinal epithelial crypt cells. The drug toxicity was dependent on drug concentration and exposure time. The data further suggest the presence of FU resistant cells, whereas cisplatin was able to induce 100% cytotoxicity. |
