Non-random double strand cleavage of DNA by a monofunctional metal complex: Binding, mechanistic, and molecular recognition studies of ((2S,8R)-5-amino-2,8-dibenzyl-5-methyl-3,7-diazanonanedioate)copper(II)

ouble strand breaks in duplex DNA are thought to be significant sources of cell lethality because they appear to be less readily repaired by DNA repair mechanisms. A study of the binding, mechanistic, and molecular recognition of ((2S,8R)-5-amino-2,8-dibenzyl-5-methyl-3,7-diazanonanedioato)copper(II) (1), which effects nonrandom double strand cleavage of duplex DNA is presented. Complex 1 creates double strand breaks via hydroxy radical...