| Malignant cancers typically become more aggressive with time. This process, termed tumor or malignant progression, is associated with phenotypic changes within the tumor, such as loss of dependence upon growth factors or hormones, development of drug resistance, tissue invasiveness and metastatic ability. The observation of differences in levels of glutathione (GSH) and related enzymes, resistance to activation of apoptosis, and induction of transcription factors suggest that (1) oncogenic progression from growth factor dependency to autonomy in the Nb2 lymphoma cell model is associated with adaptive changes in the redox state of the cell and that these changes potentiate or facilitate the tumor's progression by increasing its resistance to oxidative stress; (2) an annulment of the tumor's increased resistance to oxidative stress is related to the nuclear factor kappa B (NF... |
