Germ line genetic engineering: An analysis of principled argumentation in light of a critical theology of the body

This dissertation evaluates the ethical challenges posed by the prospect of human germ line gene transfer (GLGT). It argues that GLGT presents a new, unprecedented and complex ethical challenge. While GLGT has not yet been attempted with human beings, it has the potential not only to introduce changes into human nature that are radical and different, but also to substantially affect attitudes about human dignity and human rights. This dissertation focuses on the principled ethical arguments and the frameworks, both rational and theological, which must frame the practice of GLGT in order for it to be used in a constructive manner. Additionally it assesses which applications of GLGT are ethically acceptable, taking into account the different goals that GLGT will serve, the means by which it is practiced and the research that is required to make it possible.; Chapter One reviews the history of genetics and genetic science, locating GLGT in the context of the rapid development in genetic science and biotechnology. Chapter Two examines the history of the debates about genetic engineering and GLGT, with particular focus on the political, regulatory, and theological analyses of the 1970s–1980s. Chapter Three explores the theoretical frameworks utilized by proponents and opponents of GLGT. Utilizing categories provided by Kurt Bayertz, principled arguments are delineated and analyzed based on whether they represent a substantialist or a subjectivist approach to human nature and identity. The shortcomings of each framework taken individually, and the impasse reached by the two sides of the debate evidence the need for an expanded ethical framework. The expanded ethical framework is comprised of an enhanced critical approach that draws on the critical thought of Gerald McKenny and Michel Foucault and of an enhanced appreciation for human embodiment that draws on Pope John Paul II's theology of the body. Chapter Four applies the principles identified in Chapter Three in the course of examining: (1) the possible goals for applications of GLGT technology; (2) the ethics of the means by which germ line changes could be introduced; and (3) whether and how GLGT can be regulated.