A hisztamin- es a csontanyagcsere osszefuggeseinek vizsgalata

Histamine may be one component of the interplay between the immune system and bone metabolism; however, its exact role within this mechanism remains to be understood. Our aim was to investigate the relationship between histamine and bone metabolism.;The effect of histamine deficiency on bones was investigated in histidine decarboxylase gene knockout mice through the measuring of bone mass and serum calcitriol levels. Bone turnover markers, bone mass and fracture prevalence was determined among patients (children, postmenopausal women and men) suffering from conditions of histamine overproduction, such as allergic rhinitis. The effect of H1 receptor (H1R) antagonists and of inhalated corticosteroids on the bones was also investigated.;(1) We found a (non-significantly) greater bone mass in HDC-KO mice, and oestrogen deficiency following ovariectomy did not cause a decrease in bone mineral density in cases of histamine deficiency; (2) Serum calcitriol levels were higher in mice with histamine deficiency; (3) No correlation was detected between the markers of bone formation and bone resorption among multiplex allergic children who were not treated with H1R antagonists; however, coupling was restored and decreased bone resorption was measured in multiplex allergic children treated with H1R antagonists; (4) Femoral neck bone mineral density was lower in postmenopausal women suffering from pollen allergy in comparison to non-allergic women matched by age and anthropometric parameters; (5) Bone fracture prevalence was greater among non-treated pollen allergic postmenopausal women than among controls. Bone fractures were more frequent in women only receiving inhalated corticosteroid treatment than in women with antihistamine treatment only or a combination of antihistamine and inhalated corticosteroids; (6) Neither hip, nor clinical vertebral fractures were found in the antihistamine-treated groups, independently of corticosteroid administration; (7) Bone fracture prevalence positively correlated with body mass index in untreated pollen allergic women; (8) Bone mass and quantitative bone ultrasound parameters were (non-significantly) greater and better, while bone fracture prevalence was lower among H1R antagonist-treated pollen allergic men than among non-allergic controls.;Based on our results we can assume that histamine plays a role in the pathogenesis of bone loss caused by oestrogen deficiency. Histamine deficiency most probably influences bone metabolism through vitamin D overactivation. Our findings demonstrate the detrimental effect of allergy on fracture risk. Greater bone mass and obesity do not protect against bone fracture in allergic patients. Based on our tests the favourable effect of H1R antihistamine therapy on bones, i.e. increased elasticity can be assumed. Antihistamine therapy not only protects against the unfavourable effects of histamine overproduction on bones, but also further improves bone quality.