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Analysis Of Diabetes Hidden Structure Model And Syndrome Medication Rule Based On Data Mining

Posted on:2020-11-13Degree:DoctorType:Dissertation
Country:ChinaCandidate:L LiuFull Text:PDF
GTID:1364330599977044Subject:Chinese medical science
Abstract/Summary:PDF Full Text Request
Purpose:Firstly,from the perspective of bibliometrics,the system combs the literature in the field of diabetes syndrome research,reveals the development of the field,and finds the main leading research units and leading figures in the research field.It is intended to clearly and accurately reveal the structure of its knowledge domain,as well as the development trends and research hotspots in this field.Secondly,the medical data mining method was selected,and the clinical case data of Professor Shi Yan for treating diabetes was dataized and electronically analyzed by data mining,and analyzed by data mining.The clinical experience of diagnosis and treatment of diabetes has provided an objective basis,summed up its medication rules,and aims to provide follow-up guidance for clinical treatment of diabetes,in order to improve the clinical diagnosis and treatment capabilities of Chinese medicine.Then use the"Lantern5.0(Kongming Light)"software to study the syndrome differentiation and treatment of diabetes through the implicit structure model,explore the distribution characteristics of TCM syndromes of diabetic patients,and provide objective and reliable basis for the syndrome differentiation and treatment of diabetes in the future.Material and method:1.The research data comes from the China Journal Full-text Database(CNKI)journal database and master doctor database,Wanfang medical database,Chinese scientific journal database(VIP),as well as Google,Baidu academic and other search engines.Through the knowledge map analysis and descriptive statistics of the authors,institutions,keywords and other information contained in the journal literature and the master's thesis in the field of diabetes syndrome research,the cooperation and academic cooperation of scholars in the field of diabetes syndrome research Situations,fund support,etc.are sorted out to summarize different research themes in the field of diabetes syndrome.This study mainly applies descriptive statistical analysis,co-occurrence analysis and cluster analysis.Descriptive statistics include:the distribution of journal literature data,fund grants,journal distribution,and literature citations.The distribution of the texts of the master's thesis data,the distribution of degree-granting units,and the literature cited.Co-occurrence analysis was conducted on the authors,institutions,keywords,and instructors of the master's thesis data using the co-occurrence analysis package method.Cluster analysis was used to discover different research topics in the field of diabetes syndrome,and to predict the research trends in this field based on the research topics and the changes of keywords over time.2.This study collects and reorganizes Shi Yan's treatment of diabetes,records the prescribed prescriptions,standardizes them,and enters the“Traditional Chinese Medicine Supporting Platform System(V2.5)”to construct“Study on Treatment of Shi Yan”.The outpatient database of cravings is used to analyze and analyze the prescriptions of Professor Shi Yan for the treatment of diabetes,and summarize his academic thoughts.3.By collecting the medical records and clinical experience literature of old Chinese medicine practitioners in the database of CNKI,VIP,Wanfang Medicine,etc.,and incorporating the medical records that meet the diagnostic criteria of diabetes and Chinese medicine,and the complete diagnosis of the four diagnostic materials,constructing the hidden old Chinese medicine to treat diabetes.The structured database uses Lantern5.0 software to construct the implicit structure model,summarizes and extracts the meaning of the syndrome elements of the disease,and finds the syndrome differentiation rules of Chinese medicine.Results:1.The number of papers related to the research field of diabetes syndrome is generally fluctuating.The papers included in the research are funded by the fund.The fund with the most funding is the National Natural Science Foundation.In the papers included in the research,the proportion of Chinese core journal papers 25.07%,the most published articles are"Journal of Beijing University of Traditional Chinese Medicine"and"Chinese Journal of Traditional Chinese Medicine";the most widely used standard is"Guidelines for Clinical Research of New Drugs in Traditional Chinese Medicine";the university with the most master's degree in diabetes syndrome research is Beijing Middle School.Medical university;2.Diabetes syndrome research is widely distributed and there is cooperation among institutions.The main research institution is Dongzhimen Hospital of Beijing University of Chinese Medicine,which is mainly concentrated in the Beijing-Tianjin region and the Yangtze River Delta region.3.The author with the highest number of publications in this field is Zhao Jinxi,Dongzhimen Hospital,Beijing University of Chinese Medicine.This research area has formed a network of extensive research teamwork.4.The journal literature data and the key words of the master's thesis data show that the main research directions of diabetes syndrome research include:type 2 diabetes,diabetic nephropathy,diabetic microangiopathy,diabetic peripheral neuropathy,diabetic retinopathy and other diseases;The contents include:the distribution law of syndromes,the characteristics of syndrome elements,the treatment of syndrome differentiation,the clinical research of TCM syndromes,the research on the correlation between TCM syndromes and biological indicators,etc.Among them,the study of Qi and Yin deficiency syndrome is expected to become a syndrome of diabetes and its complications.Hot testimony of research.The main research methods include:implicit structure model,data mining,structural equation model,scale,Delphi method,correlation analysis,cluster analysis,randomized controlled trial,case series research and other methods.5.According to the criteria for inclusion,elimination and rejection of this subject,a total of336 prescriptions were selected.The results of the excavation showed that the frequency of Professor Shi Yan's commonly used drugs for treating diabetes in the outpatient clinic of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine was frequent.Sorted from high to low,the top 10 drugs:licorice,astragalus,berberine,medlar,atractylodes,Huangjing,red ginseng,salvia,puerarin,Schisandra;drug selection tends to be mild drugs;drug taste is most commonly used for sweet,bitter and spicy Drug return to the spleen is the most common,followed by the stomach,lung drugs;6.The drug is most common with Astragalus and Licorice,Licorice and Lycium,Coptis and Licorice,Astragalus and Poria.Five new prescriptions for treating diabetes have been excavated.7.In this study,13 hidden categories of 119 old Chinese medicine treatments for diabetes were initially extracted by implicit analysis.8.According to the interpretation,the common syndromes of diabetes include spleen and kidney yang deficiency syndrome,spleen deficiency and dampness syndrome,yang deficiency water syndrome,damp heat internal syndrome,yin deficiency and heat syndrome,etc.,involving spleen,stomach,Kidney,liver,lung,heart and other organs,involving qi stagnation,phlegm,qi stagnation,kidney deficiency,qi deficiency,spleen deficiency,spleen yang deficiency,virtual heat,yin deficiency and so on.9.This study analyzes the medical records through the Chinese medicine inheritance platform.Among them,the diabetic nephropathy involves a total of 214 Chinese medicines.The top three high-frequency drugs are Astragalus,Poria,Chinese Yam,Astragalus and Poria,Astragalus and Alisma,and Yam.The highest number of occurrences with cockroaches;10.Diabetic retinopathy medication involves a total of 214 Chinese herbal medicines.The top three high-frequency drugs are Alisma,Poria,Hawthorn,and the combination of Astragalus,Hawthorn and Chinese Yam,Hawthorn and Poria has the highest number of occurrences;11.Diabetes gastrointestinal lesions medication analysis involves a total of 116 Chinese medicines,the top three high-frequency drugs for Alisma,Poria,Hawthorn,??and Alisma,hawthorn and yam,hawthorn and cockroaches have the highest number of occurrences;12.Diabetes peripheral neuropathy medication involves a total of 160 traditional Chinese medicines.The top three high-frequency drugs are Alisma,Poria,Hawthorn,and the combination of Astragalus,Hawthorn and Chinese Yam,Hawthorn and Poria are the highest.Conclusion:1.The Institute of Correlation in the Field of Diabetes Syndrome has received more attention and has no heat loss,and has high research value.The expressions of keywords and syndromes in the relevant literature should be standardized to facilitate the research of bibliometrics.2."Journal of Beijing University of Traditional Chinese Medicine","Chinese Journal of Traditional Chinese Medicine","Liaoning Journal of Traditional Chinese Medicine","Chinese Journal of Basic Medicine of Traditional Chinese Medicine","Chinese Journal of Integrated Traditional Chinese and Western Medicine","Chinese Journal of Traditional Chinese Medicine","Chinese Medicine"The Journal and the Clinical Research of Traditional Chinese Medicine are closely followed by the field and are the main journals.3.Beijing University of Traditional Chinese Medicine,Guangzhou University of Traditional Chinese Medicine and Chengdu University of Traditional Chinese Medicine have published a high volume of papers in this field.They have paid more attention to diabetes syndrome research,and their emphasis has been continuously improved.Among them,the number of published papers of Beijing University of Traditional Chinese Medicine is much higher than that of other universities,and it is at the leading level.The research literature has received more funding and is mainly funded at the national level.Dongzhimen Hospital of Beijing University of Chinese Medicine,Guang'anmen Hospital of China Academy of Chinese Medical Sciences,Beijing University of Chinese Medicine and Oriental Hospital of Beijing University of Chinese Medicine,etc.,with a large number of grants and more types;the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin Traditional Chinese Medicine Funding for universities and Liaoning University of Traditional Chinese Medicine is not dominant,but the effect of fund funding is significant.Other institutions,including Henan College of Traditional Chinese Medicine,Zhejiang University of Traditional Chinese Medicine,and Chengdu University of Traditional Chinese Medicine,have little difference in the proportion of funds invested and papers.4.The quality of journal articles in this field is relatively high,and the high-quality papers in Shuobo are relatively insufficient.5.In the research cooperation team,Dongzhimen Hospital of Beijing University of Chinese Medicine is the most widely cooperated institution in the field of diabetes syndrome research.Beijing University of Chinese Medicine,Guang'anmen Hospital of China Academy of Chinese Medical Sciences,Oriental Hospital of Beijing University of Chinese Medicine,Tianjin University of Traditional Chinese Medicine A subsidiary hospital is a relatively active institution,and their cooperation is centered on the core institutions and has close cooperation.6.Zhao Jinxi team of Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine,Ni Qing team of China Academy of Chinese Medical Sciences,Wang Wei team of Beijing University of Chinese Medicine and Fuxin team of Hangzhou Red Cross Hospital,the above team will likely lead the field of diabetes syndrome in the next few years Research.Applying cluster analysis,implicit structure model and medical data mining methods,research on diabetes syndrome will become a hot topic.7.This study uses data mining methods to statistically analyze the rules and characteristics of Professor Shi Yan's treatment of diabetes.He believes that the occurrence of diabetes is based on yin deficiency or qi deficiency,phlegm and blood stasis as the standard,and most of them are false and complex.disease.Turbidity is the pathological basis of blood stasis formation,and the two affect each other.The blood stasis runs through diabetes,and the treatment of"spleen phlegm,phlegm and blood stasis"is the core method;8.Professor Shi Yan's clinical application of the drug is highly consistent with the main ingredients of the traditional Chinese medicine compound Yitangkang,highlighting Professor Shi Yan's overall adjustment of the human yin and yang balance,focusing on syndrome differentiation and treatment,taking into account both the symptoms of spleen and phlegm,promoting blood circulation and removing blood stasis.To alleviate various symptoms of diabetic patients,to reduce blood sugar,and to stabilize the effect;9.Professor Shi Yan is proficient in the medicinal properties of drugs,yin and yang,and moisturizing and drying.Through the flexible application of medicinal properties,he corrects the yin and yang of the disease or the partial decline,in order to achieve the body's"Yin Ping Yang secret",so that the patient's symptoms are improved;10.Professor Shi Yan took the idea of“Yin deficiency heat,spleen deficiency and loss of luck”as the main starting point to discuss the idea of treating diabetes.More choices were licorice,astragalus,medlar,red ginseng and other sweet-sweet drugs to replenish spleen and qi,and choose Huanglian and Phellodendron.The bitter-tasting drugs use the scent-flavored drugs such as cassia twig and aconite to help the yang qi;11.The combination of Astragalus and Glycyrrhiza has the highest frequency of drug combination.The combination of the two drugs enhances the qi and spleen.It reflects the academic thought of Professor Shi Yan's"treatment from the spleen"and confirms that the traditional Chinese medicine compound Yitangkang"Huang Wei,The rationality and scientificity of the licorice"medicine pair".12.Clinical treatment found that patients with diabetes have more symptoms of spleen deficiency such as“thirst and polydipsia”,“sufficiency”and“smoothness”.The comprehensive drug frequency is ranked in the top three licorice,astragalus and medlar.Attaching importance to restoring the physiological functions of the spleen and stomach,and grasping the core pathogenesis of the spleen and the health,it reflects the academic thought of Professor Shi Yan's"treatment from the spleen".13.This study through implicit analysis and interpretation:the common syndromes of diabetes include spleen and kidney yang deficiency syndrome,spleen deficiency and dampness syndrome,yang deficiency water syndrome,damp heat intrinsic syndrome,Yin deficiency and heat syndrome,etc.It involves spleen,stomach,kidney,liver,lung,heart and other organs,involving qi stagnation,phlegm,qi stagnation,kidney deficiency,qi deficiency,spleen deficiency,spleen yang deficiency,virtual heat,yin deficiency and so on.
Keywords/Search Tags:Diabetes, TCM syndrome, Citespace, VOSviewer, medical data mining, medication rule, hidden structure model
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