Discussions On The Law Of Treating Chronic Obstructive Pulmonary Disease By Ancient And Modern Lingnan Doctors Based On Literature Research And Data Mining Technology

ObjectiveIn the development of Chinese medicine,different medical schools have promoted the prosperity and development of traditional Chinese medicine.Lingnan medicine,as a branch of traditional Chinese medicine,has a distinct local color.Lingnan medicine has a long history.Lingnan medical doctors have rich experience in treating pulmonary cough and asthma syndrome,and the medicine for diagnosis and treatment is rich in Lingnan characteristics.The traditional Chinese medicine literature preserved in the dynasties of the Lingnan area is rich in content,which contains infinite wisdom,has important inherited functions,and has academic ancl applied value.Although China has intensified the protection of the ancient Chinese medical literature,so that the protection environment of-the literature has been improved,but over time,the ancient books will inevitably appear damaged or even lost,and the valuable experience of the predecessors is submerged in The possibility of history is long.Based on the medical literature carrying the experience of medical doctors in the past and the idea of diagnosis and treatment,this study aims to collect and collect the ancient books on the syndromes of Pulmonary disease and chronic obstructive pulmonary disease in Lingnan traditional Chinese medicine before the end of the Qing Dynasty and the Qing Dynasty.The medical doctor's understanding and development of the treatment of chronic obstruct ive pulmonary disease in Chinese medicine,and the establishment of the Lingnan medical literature database for review and retrieval,strengthen the protection and development of the literature resources.From ancient times to the present,the Lingnan medical doctors of the past dynasties have different characteristics.The medical records can directly reflect the doctor's clinical experience and acaciemic thoughts,and collect and organize the representative Chinese medicine practitioners in Lingnan.In the case,the application of data mining technology to explore the drug use law of the medical case,the ancient and modern mutual reference,summed up the etiology and pathogenesis of the chronic obstructive pulmonary disease syndrome in Lingnan area and the local characteristics of the use of prescription drugs.We hope that this topie can present the valuable academic thoughts and experience of the past,and provide reference for the clinical,teaching and scientific research activities of the lung specialist diseases,and provide materials and resources for the inheritance and innovation of Lingnan Medicine to facilitate the later generation.MethodsThis thesis uses literature research and data mining methods to complete the writing of the thesis.The literature research methods include literature combing,comparative analysis and theoretical review based on the collection of first-hand literature data.Data mining methods include descriptive analysis,association rules,LDA topic analysis,etc.To comprehensively collect and sort out the medical literature of Lingnan medical doctors in the past,and to consolidate the academic opinions of various dynasty doctors on treating chronic obstructive pulmonary disease,and use the collected medical literature as the data source to construct the treatment of Lingnan medical doctors.The literature database of Kechuan;the data mining method was used to analyze the drug rule after the collection and screening of the hospital.Under the guidance of the theoretical knowledge of traditional Chinese medicine,the data mining results were discussed.The results of the literature research,the ancient and modern mutual reference,summed up the etiology and pathogenesis of the chronic obstructive pulmonary disease syndrome in Lingnan area and the local characteristics of the use of prescription drugs.ResultsA total of 19 qualified ancient books were collected:Jin,ge hong "elbow backup nasty party",song,Chen in compendium of material medica and treasure the peaceful holy benevolence formulae,Ming·ChengDuan Cheng Zhai medical copy close this,Ming Ming,Wang Guan Ming medical miscellaneous",Ming.Zhang Jike "three collection",Ming.Feng Shike all the wonderful XianFang,qing,liu yuanhai medical code "to",the qing,Guo Yuanfeng treatise on febrile disease,qing,He Mengyao medical Bian,qing,Huang Xiao peng the song"thermomechanical constitutive modeling of the zoo,pan qing,who bear the review harp slightly random medical and enclosed to leaf case,qing,Chen Xi prescriptions do not ask for,qing,Chen Zhenge" medical classes always pivot"and the late qing and early republic Huang Enrong Hui creek basis method of tang dynasty,Lu Jiao fool sleep company basis of data processing,Chen botan has read treatises on febrile diseases and the jinguivolumes xix.In the data mining part,166 cases related to the treatment of cough and asthma syndrome by 43 physicians in contemporary lingnan region were included,with 192 traditional Chinese medicines,and the occurrence frequency of drugs was 1792 times in total.This subject takes lingnan area as the research scope,according to the order of dynasties,from jin,song,yuan,Ming and qing dynasties to the republic of China,to collect and study lingnan doctors and their writings in existence,to summarize their academic essence,and to summarize their clinical characteristics in treating chronic obstructive pulmonary disease.Through these ancient medical books,we can get a glimpse of lingnan medical experts' academic innovation in adapting measures to local conditions,and select corresponding existing writings,extract original medical books,build literature database,and realize the circulation and sharing of resources.This paper collected and sorted out the medical cases of diagnosis and treatment of chronic obstructive pulmonary disease by famous traditional Chinese medicine doctors in guangdong province since the republic of China,established the modern lingnan famous lung department cough and asthma medical case database,and applied data mining technology to explore the law of syndrome treatment.In article included in the study of 166 prescriptions,common traditional Chinese medicine 192,a total of 1792 times,present frequency during the drug use most of the top 20 Chinese herbal medicine for:liquorice,pinellia,poria cocos,dried tangerine or orange peel,almond,atractylodes,Perilla,fructus schisandrae,dangshen,coltsfoot flower,peach kernel,ephedra herb,radix ophiopogonis,radix scutellariae,phlegm,unibract fritillary bulb,white mulberry root-bark,asarum,radix paeoniae alba,white mustard,accounts for more than half of all drugs,drug use the most frequency for dryness of wet phlegm.Spoken by the largest number of top 15 drugs:mend angry medicine,cough antiasthmatic,thanh hoa heat phlegm drugs,warms cold phlegm,qi,divergence of cold medicine,the water swelling,heat of poison,Yin drugs,blood tonic medicine,invigorate the circulation of emmenagogue,ultimately,in medicine,the folding of the lung astringent medicine,and drugs,such as heat,dry wet phlegm cough antiasthmatic ranks the first place,the second is to fill empty medicine;As a whole,the proportion of warm and cold drugs is much higher than that of cold and cold drugs.Drugs used to gan,xin,bitterness,mainly attributed to the lung,spleen,followed by the stomach,heart,kidney.USES the Apriori algorithm for association rules between drug analysis,set confidence(confidence)of 0.5 or higher,support(support)of 0.15 or higher,the results showed that this decoction,dried tangerine or orange peel,poria cocos,atractylodes,dangshen,Perilla seed,almond,fruit of Chinese magnoliavine,phlegm,coltsfoot flower is the main drug treatment to cough and gasp the,more than 15%of the prescriptions of using these drugs,including pinellia and dried tangerine or orange peel,poria cocos and pinellia,poria cocos and compatibility are the most comnon use of orange peels,commonly used to include:poria cocos,dried tangerine or orange peel,pinellia tuber;Asters and buttercups;Orange peel and pinellia ternata;Atractylodes macrocephala and poria cocos;Radix codonopsis and pinellia ternata;Tuckahoe and pinellia tuber;Radix codonopsis and atractylodes;Orange peel and poria cocos;Dangshen and tangerine peel;Perilla fruit,pinellia ternata,among them the medicine of 3 traditional Chinese medicine has tuckahoe,orange peel,pinellia ternata.According to the analysis results of the LDA model,the core drugs in the eight core prescriptions were obtained:the first theme was the combination of high frequency drugs with phlegm-heat obstructing the lung and manifested by chronic obstructive pulmonary disease:dilong,liquorice,almond,scutellaria,fritillaria,houttuynia,loquat leaf,forsythia,plantain seed and ephedra.The second theme is qi-stagnation phlegm type chronic obstructive pulmonary disease high frequency drug combination:almond,peach kernel,radix ophiopogonis,radix scutellariae,draba nemorosa,ginseng,fritillary bulb,loquat leaf,Perilla seed,fructus trichosanthis.The third theme is the combination of chronic obstructive pulmonary disease drugs with lung and spleen deficiency:liquorice,pinellia ternata,poria cocos,orange peel,atractylodes macrocephala,Perilla,codonopsis pilosula,almond,schisandra fruit,coltsfoot.The fourth theme is the combination of high frequency chronic obstructive pulmonary disease drugs with Yin deficiency and blood stasis:red peony root,suberect spatholobi,radix herba deserticola,aloes,dried ginger,schisandra fruit,bamboo leaf,mirabilite and radix scrophulariae.Theme five is the combination of high frequency chronic obstructive pulmonary disease drugs with qi and Yin deficiency:radix ophiopogonis,fructus schisandrae,fritillary bulb,panax notoginseng,astragalus,licorice,salvia miltiorrhiza,American ginseng,nansha ginseng and lily.Theme 6 is phlegm and blood stasis obstructing lung type of chronic obstructive pulmonary disease high-frequency drug combination:red peony,safflower,draba nilio,peach kernel,angelica,motherwort,chuanxiong,salvia miltiorrhiza,hyssop,pinellia.The seventh theme is the combination of high frequency chronic obstructive pulmonary disease drugs with phlegm-dampness-retardation:fritillary bulb,licorice root,stiff silkworm,coix seed,semen cheicicis,angelica,orange peel,dilong,anemarrhena,magnolia officinalis.Theme eight is the combination of high frequency drugs for chronic obstructive pulmonary disease with phlegm-heat and lung depression:coix seed,winter melon seed,houttuynia cordata,reed stem,peach kernel,zhejiang fritillaria,white mulberry bark,Scutellaria,pinellia and radix platycodonis.ConelusionLingnan medical experts had their own characteristics in treating chronic obstructive pulmonary disease from different aspects.Overall,lingnan ancient physicians think to cough and gasp the reversed flow of qi pathogenic emphasize on pathogenesis,disease or because of the evil,or because the virtual,or both,thought that the basic pathological characteristics of the virtual to real,factors,and the deficiency of lung and spleen deficiency,late involving heart kidney,the real is associated with phlegm and blood stasis and invaded by the invasion,deficiency of phlegm and blood stasis throughout the course of the disease has always been.Combining with the regional characteristics of Lingnan,it reflects that Lingnan is prone to encroach on the lungs of Shangjiao and cause asthma,distension and cough.Attaching importance to the treatment of spleen is the key to the prognosis of the disease.The results of data mining suggest that modern lingnan medicine for chronic obstructive pulmonary disease mainly has the effects of eliminating phlegm and asthma,invigorating the spleen and moistening the spleen,clearing the lungs and relieving cough,as well as supplementing qi and Yin.The drugs used were mainly temperature-based;Drug taste to gan,xin,bitter;Pinellia ternata,tuckahoe and tangerine peel are the core drug combination for the treatment of chronic obstructive pulmonary disease.Eight groups of high-frequency drug combinations suggested that there were eight common syndromes of chronic obstructive pulmonary disease in Lingnan area,which were phlegm-heat obstruction syndrome,qi-stagnation-phlegm obstruction syndrome,lung-spleen deficiency syndrome,Yang-deficiency and blood stasis syndrome,Qi-Yin Deficiency syndrome,phlegrrrstasis obstruction syndrome,phlegm-dampness obstruction syndrome and phlegm-heat stagnation-lung syndrome.The location of the disease is mainly in the lung and spleen,and the heart and kidney are involved in the later stage.The pathological nature of the disease is the mixture of deficiency and deficiency.The deficiency involves the deficiency of the lung,spleen and kidney,which is marked as phlegm turbidity,blood stasis or phlegm and blood stasis.Due to the dampness and heat in lingnan area,dampness can block spleen Yang,and phlegm and blood stasis,qi deficiency,phlegm turbidity and blood stasis run through the whole course of the disease.The key to the treatment of chronic obstructive pulmonary disease is to pay attention to invigorating the healthy qi,regulating qi and blood,reducing and relieving asthma,using drugs,supplementing combined application,treating specimens and eliminating phlegm with dryness and dampness.By synthesizing the research results of ancient and modern Lingnan physicians on treating chronic obstructive pulmonary disease,we can find that the etiology,pathogenesis and syndrome differentiation and treatment of cough and asthma have both the same origin and the new creation.The pathogenesis of Lingnan chronic obstructive pulmonary disease is mainly based on lung spleen qi deficiency and phlegm obstruction,and the treatment is based on spleen and phlegm.No matter the ancient and modern,tangerine peel and pinellia,it is the most used drug.This is inseparable from Lingnan' s special geographical environment and human group quality,and it is also the most important and most important regional feature of Lingnan Medicine.The pathogenesis of acute exacerbation of Zhongyuan Medicine is the key to the mutual resistance.Blood stasis is the main path of the disease.The main path of the Lingnan cough and asthma syndrome is turbidity instead of blood stasis.It is rare to see the cold of the Central Plains medicine,such as the cold,the cold,the inner cold drink,the Yimeng Shenque,but the heat syndrome is more coumon in the heat.In the treatment,the emphasis is on clearing heat and resolving phlegm,drying dampness and invigorating the spleen,promoting lung and reducing qi,and promoting blood circulation and removing blood stasis.In the stable period,nourishing qi and invigorating the lung and invigorating the spleen and resolving phlegm are the main methods.