UCP2 Regulates M1 Macrophages Infiltration In Gingiva With Periodontitis

Periodontitis is an inflammatory disease accompanied by alveolar bone loss.Ml macrophage play critical roles in the development of periodontal disease.Uncoupling protein 2(UCP2)which are mitochondrial transporter proteins control M1 macrophage activation by modulating the production of reactive oxygen species(ROS).We investigated the role of UCP2 on M1 macrophage infiltration in the gingival tissues with periodontitis.We found that the expression of UCP2 was upregulated in the M1 macrophage infiltrated in human gingival tissues with periodontitis.Macrophage specific knockout UCP2 could exacerbate inflammatory response in mice gingiva affected with periodontitis.The loss of UCP2 may contribute to the enhanced abilities of proliferation,migration,pro-inflammatory cytokines execration and ROS production in Porphyromonas gingivalis-LPS treated macrophages.Our results indicate that UCP2 is an important player in M1 macrophage polarization in the periodontal tissue in periodontitis.