Evaluation Of Cerebral Microbleeds In Essential Hypertension Using Quantitative Susceptibility Mapping:a Clinical Study

Part ?:Detection and Assessment of Essential Hypertension Cerebral Microbleeds Using Quantitative Susceptibility Mapping:Prevalence and SusceptibilityObjective:QSM sequence is the best method to detect the total iron content in the issue and it is very sensitive to CMBs detection.In this study,we will discuss the regularity of magnetic permeability where CMBs distributed in our brain by detecting the number of CMBs incidence location as well as where how the magnetic permeability change were discussed.Methods:Using GE 3.0T Discovery 750 type superconducting MRI scanner to scan routine MRI sequence and QSM sequence for 37 patients who are not only primary hypertension patients but also CMBs.Finding the difference between the cerebral MRI scan and QSM sequence.According to the QSM inspection situation,and the CMBs grouping criteria,we divide brain space into three regions,which are basal ganglia-thalamic area,cortical-subcortical area,and subcontract area.The number of lesions in different detection methods and different areas was compared.P<0.05 considered the difference statistically significant.Results:In this study,there were 198 CMBs lesions in the QSM sequence of 37 patients with primary hypertension,of which 16 were found with 36 lesions on the corresponding conventional sequence.The number of CMBs lesions and the number occurred in the basal-thalamus lesion number is 129,the number of lesions in cortex-subcortical area is 46,the number of lesions in under tentorium area is 23.CMBs lesions of magnetic susceptibility value range from0.112 to 0.494,the mean is 0.2510.Using single-factor analysis of variance to compare magnetic susceptibility values and lesion area of CMBs lesions in three different spatial locations,showing that there was no significant difference in the lesion area of CMBs between the three different regions(P>0.05),and CMBs lesion magnetization.The difference in rate was statistically significant in three different regions(P<0.05).Conclusion:QSM sequences are significantly better than conventional sequences for CMBs detection and much more sensitive to detect CMBs.The values of magnetic susceptibility of CMBs lesions detected by QSM sequence can reflect the lesions,the total iron content in occurrence of micro distribution in different parts of the brain bleeding lesions is magnetic susceptibility value follows certain rules and change.Part ?:Assessment of QSM Sequence on Primary Hypertension CMBs:Clinical AssociationObjective:To explore the correlation between the magnetization rate and area of CMBs in three different spatial distribution sites,and to evaluate the importance of clinical risk stratification for primary hypertension.Methods:Using the US GE 3.0T Discovery 750 superconducting magnetic resonance scanner,QSM sequence scanning was performed on 37 patients with essential hypertension and CMBs.Magnetic susceptibility values and area values of CMBs were measured at various sites.CMBs were analyzed at different sites.The correlation between magnetic susceptibility values and the area of the QSM original image;analysis of the correlation between magnetic susceptibility values of CMBs lesions at different sites and baseline data of EH patients.Results:The magnetic susceptibility value of different space distribution where CMBs lesions located in different risk stratification have statistical significance.Basal ganglia,thalamus area corresponds to the magnetic susceptibility values of primary hypertension risk stratification,systolic pressure,diastolic blood pressure,age,course of diseases have correlation.The area of the lesion in the original image of QSM was positively correlated with the magnetization rate.Conclusion:This study included a total of 37 patients with essential hypertension.The magnetic susceptibility values of CMBs in different spatial distribution sites were statistically significant among different risk stratification groups;magnetic susceptibility values of basal ganglia-thalamic lesions and risk stratification of essential hypertension,systolic blood pressure,diastolic blood pressure,age,The course of disease was correlated(r = 0.705,0.462,0.580,0.547,P<0.05).There was a positive correlation between the area of lesions on the QSM original image and the magnetic susceptibility values in each area(cortical-subcortical area:r=0.698,P=0.000;basal ganglia-thalamic area:r=0.435,P=0.000;under the tentorium area:r=0.453,P=0.030).