Research And Biomechanical Analysis Of A New Designed Cervical Fusion Cage

Anterior cervical discectomy and fusion(ACDF)is a commonly used surgical treatment for cervical spondylosis,mainly used for anterior cervical compression.When the decompression of the cervical spine or cervical cord,this type of surgery can reduce the damage of the nerve tissue.At the same time,it can be inserted into the interbody fusion cage and accompanied by anterior fixation of the vertebral body.It can maintain the height of the intervertebral foramen and facilitate fusion.With the increasing use of cervical ACDF in clinical practice,how to design and prepare intervertebral fusion cages with appropriate materials has received more and more attention from spine surgeons.It is also a hot spot in the development of spinal surgery.Purpose:1.Design the shape of a new type of cervical interbody fusion cage using Mimics software;2.Simulate human normal bone tissue structure and prepare silk fibroin nano-hydroxyapatite composite material;3.A new type of cervical interbody fusion cage was prepared by 3D printing and its biomechanical function was evaluated.Method:1.Three-dimensional CT images of the cervical spine obtained from volunteer scans were imported into Mimics software to establish cervical spine.The dimensional model simulates the vertebral body shape after cervical ACDF surgery and designs the shape of the intervertebral cage.2.The degummed silk fibroin is contacted with a proteolytic agent to obtain a solution containing dissolved fibroin where in the photolytic agent comprises calcium chloride,ethanol and water,and the dissolved fibroin and hydrogen phosphate are dissolved.The aqueous diammonium solution is reacted,and the reaction system is made alkaline.The reaction product is washed and freeze-dried to obtain a composite material of silk fibroin and hydroxyapatite.Characterization was determined by scanning electron microscopy(SEM),X-ray diffraction(XRD)analysis,and infrared spectroscopy(IR).3.The silk fibroin and hydroxyapatite composite material 3D direct write layer-by-layer printing,and then molding,drying and modified to obtain a new cervical fusion cage.The compression modulus test of a new type of cervical fusion cage was performed by an electronic universal material testing machine;the elastic modulus test of a novel cervical fusion cage was measured by a dynamic resonance method using a dynamic elastic modulus tester;the finite element analysis was performed.In Vivo Biomechanical testing of a new Cervical Fusion cage.Result:1.Three-dimensional cervical vertebra model was established by using Mimics software combined with clinical CT image data;the changes of the anatomy of the vertebral body following cervical ACDF surgery were simulated and measured;the shape of a personalized cervical fusion cage was designed.2.Silk fibroin composites were prepared and confirmed by scanning electron microscopy(SEM),X-ray diffraction(XRD)analysis,and infrared spectroscopy(IR)analysis;composites have a bone mass in humans The same structural organization and composition.3.Using 3D write-through layer-by-layer printing technology to prepare a new type of composite cervical cage fusion device,which has excellent characterization,and has a higher compressive strength and a suitable elastic modulus.Finite element analysis demonstrated that the new composite cervical cage has a good biomechanical strength in vivo.Conclusion:Mimics software can be used to model the cervical ACDF before surgery,and the shape of the cervical fusion cage is designed.Using innovative preparation methods,silk fibroin/nanohydroxyapatite composites have been fabricated and have good biomechanical characteristics and biological activity.By in vitro compressive strength and in vivo biomechanical analysis using finite element analysis,the new composite cervical cage has good biomechanical strength,meets the requirements of clinical surgery,can effectively achieve bone graft fusion,and effectively prevent under the vertebral body,the cervical ACDF surgery to achieve satisfactory patient treatment.