| Purpose:1.Using "Knowledge Discovery in Database" technical statistics to analyze the TCM pattern of syndrome of 904 cases of Tourette syndrome(TS)and explore the law of symptomatology and summarize the syndrome factors of TS.2.Using "Knowledge Discovery in Database" methodology statistics to analyze the morbidity of TS patients complication(obsessive compulsive disorder,attention deficit hyperactivity disorder,anxiety,depression,enuresis)and explore their TCM syndrome law and syndrome factors.3.Using "Knowledge Discovery in Database" methodology statistics to analyze the microelement distribution,immune globulin,erythrocyte sedimentation rate,ASO indictor of TS patients and explore the characteristics of microelement and immunological indicators of TS patients.Method:Literature research and deep interview and other methods are adopted to sort out the clinical cases in a regulated way,and computer data mining technology is combined organically to sort out and mine the data,so as to mine and summarize the information.Through deep interview with the tutor,it is to summarize the academic thought of the tutor in the treatment of Tourette syndrome and the law and efficiency to treat this disease and analyze the distribution law of TS multiple species diseases.Result:1.Analysis on general condition of TS1.1 Onset age,sex ratio,heredity904 cases were included,including 700 male cases and 204 female cases,with a sex ratio of 3.43:1,and the conclusion made was consistent with the literature report.The minimum of onset age was 3 years old,and the maximum one was 18 years old,with an average onset age of 8.93±0.29,including 113 cases(12.50%)for 3-5 years old,267 cases(29.54%)for 6-8 years old,308 cases(34.07%)for 9-11 years old,165 cases(18.25%)for 12-14 years old and 51 cases(5.64%)for 15-18 years old,in which the patients of 9-11 years old had the highest morbidity.According to the investigation on the family history of the child patients,it was found that 141 child patients(15.60%)had a family history,with a certain family heredity.1.2 Distribution of TS multiple species diseases111 cases of TS multiple species diseases were included,including 91 cases(81.98%)of common ADHD,12 cases(10.81%)of common enuresis,5 cases(4.50%)of common OCD,2 cases of common depression and 1 case(0.90%)of common autism.1.3 Predisposing factors105 patients(11.62%)had upper respiratory infection before morbidity,102 patients(11.28%)played game or are addicted to game software in game,102 patients(11.28%)watched TV for a long time,94 patients(10.29%)had improper education manner,63 patients(6.97%)had too heavy learning burden and 41 patients(4.54%)often drank carbonated beverage.1.4 Analysis on seriousness of tic disorderAccording to the evaluation criteria of Yale Integrated Tic Disorder Seriousness Scale,before treatment,there were 15 cases of serious tic disorder(1.66%),96 cases(10.62%)of significant tic disorder,272 cases(30.08%)of moderate tic disorder,312 cases(34.51%)of mild tic disorder and 209 cases(23.12%)of slight tic disorder.After treatment,there was 0 case(0.00%)of tic disorder,1 case of significant tic disorder(0.11%),10 cases(1.11%)of moderate tic disorder,103 cases(11.39%)of mild tic disorder,413 cases(45.69%)of slight tic disorder and 377 cases(41.70%)of no tic disorder.1.5 Efficiency of western medicine7 cases(0.77%)controlled clinically in the first diagnosis,1 case(0.11%)significantly effective,59 cases(6.53%)effective and 837 cases(92.59%)ineffective.57 cases(6.30%)controlled clinically in the second diagnosis,31 cases(3.43%)significantly effective,207 cases(22.90%)effective and 609 cases(67.37%)ineffective.1.6 Efficiency of TCM symptom844 cases(93.36%)controlled clinically in the first diagnosis,0 case significantly effective,0 case effective and 60 cases(6.64%)ineffective.827 cases(91.48%)controlled clinically in the second diagnosis,0 case significantly effective,0 case effective and 77 cases(8.52%)ineffective.1.7 Efficiency of multiple species diseasesAfter treatment,1 case(1.1%)of common ADHD was controlled clinically,5 cases(5.5%)effective,79 cases(86.8%)effective and 6 cases(6.6%)ineffective;0 case of common OCD was controlled clinically,0 case significantly effective,5 cases(100%)effective and 0 case ineffective;2 cases(100%)of common depression clinically controlled and 1 case(100%)of common autism clinically controlled.1.8 Symptom distribution frequencyIn the 2712 diagnoses,according to the frequency,the symptom distribution is as follows:blinking 567 times(10.23%),impatience 540 times(9.74%),jumbling 453 times(8.17%),inattention 422 times(7.61%),nose suction 372 times(6.70%),timidity 371 times(6.70%),neck twisting 321 times(5.79%),shoulder shrugging 318 times(5.73%),frowning 269 times(4.85%),head shaking 245 times(4.42%),eye rolling 214 times(3.86%),grinning 183 times(3.30%)and hand swinging 174 times(3.14%).2.Experience of tutor in treatment of TS2.1 TCM pattern of symptom distribution lawSpleen deficiency and liver hyperaction 1423 cases,accounting for 52.43%,spleen deficiency and phlegm collection,26.59%,Yin deficiency 240 cases 9.85%,qi depression transforming into heat 313 cases,7.85%,liver hyperaction 81 cases,2.99%,internal phlegm heat 36 cases,1.32%.2.2 Treatment methodThe common treatment methods for 904 cases in the preliminary diagnosis were respectively spleen tonifying 714 times,accounting for 79.87%,liver calming 501 cases,55.42%,phlegm reducing 252 times,27.88%,dizziness relief 107 times,11.84%,Yin nourishing 80 times,8.85%and heat discharging 71 times,7.85%.2.3 Drug use law215 traditional Chinese medicines were involved in total,in which Chinese parsnip root 1926 times,accounting for 5.49%;pawpaw 1504 times,4.29%;pipewort 1487 times,4.24%;lycopodium clavatum 1434 times,4.09%;pericarpium citri reticulatae 1392 times,3.97%;Rhizoma Pinellinae Praeparata 1388 times,3.96%;radix paeoniae alba,3.71%;Radix Puerariae 1240 times,3.54%;uncaria 1166 times,3.33%;Poria cocos 1127 times,3.21%;Ligusticum wallichii 1105 times,3.15%;Schizonepeta 1101 times,3.14%;lumbricus 1094 times,3.12%;Chinese yam 1064 times,3.03%;rhizoma acori graminei 936 times,2.57%;radix bupleuri 850 times,2.42%;arisaema cum bile 782 times,2.23%;chrysanthemum 782 times,2.23%;radix curcumae 683 times,1.95%;radix pseudostellariae 641 times,1.83%,and selfheal 571 times,1.63%etc.2.4 Drug categoryRelief drug 6754 times,deficiency tonifying drug 5173 times,phlegm reducing drug 3674 times,liver calming and dizziness relief drug 3618 times,wind-damp expelling drug 3548 times,blood activating and stasis dissolving drug 2197 times,vital energy regulating drug 1197 times,awaking drug 936 times,nerves calming drug 541 times,dampness resolving drug 201 times,astringency inducing drug 97 times.2.5 Drug channel tropismLiver channel 20980 times,spleen channel 18079 times,lung channel 16839 times,stomach channel 8368 times,kidney channel 6070 times,urinary bladder 3647 times,gallbladder channel 3418 times,pericardium channel 2289 times,large intestine channel 1145 times2.6 Drug functionWind dispelling drug 7810 times,heat clearing drug 6515 times,pain relief drug 6454 times,liver calming drug 5280 times,spleen tonifying drug 4675 times,phlegm reducing drug 4604 times,dampness eliminating drug 4500 times,relief drug 4182 times,collateral activating drug 4035 times,eyesight improving drug 3639 times,saliva generating drug 3551 times,stasis removing drug 3430 times,dizziness relief drug 3266 times.2.7 Drug tastePungent drug 17908 times,sweet drug 14488 times(25.90%),bitter drug 12812 times(22.91%);sour drug 3385 times(6.05%);salty drug 2485 time(4.44%);slightly bitter drug 2407 times(4.30%),flat-taste drug 1168 times(2.09%).Moderate 11253 times(32.69%),mild drug 7289 times(21.18%),cold drug 488 times(14.20%),slightly cold drug 4439 times(12.90%),slightly moderate drug 3293 times(9.57%)and cool medicine 3235 times(9.40%)etc.Conclusion:1.Boys have a higher TS morbidity than girls;with onset age frequently in the pre-school age and school age and average disease course above 2 years;the most frequent symptom in TS patients is blinking of motor tics,followed by sounding jumbling,then nose suction,neck suction,neck twisting,shoulder shrugging,frowning,head shaking and eye rolling etc.The tic of head and face is relatively frequent,while hand swinging,stomping,bulging and other tics of limbs and abdomen are less frequent.2.There is a large difference in result of western medicine efficiency rating scale and traditional Chinese medicine rating scale,the result of traditional Chinese medicine efficiency tends to be clinical control,and the rating criteria of for the western medicine efficiency is relatively high,so the rating result of western medicine efficiency is difficult to reach the clinical control.In consideration that the objective rating criteria of the Chinese medicine rating scale is insufficient,further improvement is needed in design.3.Among the common multiple species diseases of TS patients,ADHD accounts for the majority,followed by enuresis,OCD,depression and autism.4.The summary of the tutors treatment of TS and its multiple species diseases is often proposed from the aspect of "wind" and "phlegm" and the thought that disease is from liver and spleen,which reflects the dialectical thinking of the tutor’s treatment of this disease from the common treatment method and drug use law. |
PDF Full Text Request