| Objective:To observe the clinical therapeutic effect of electro-acupuncture and PFMT with solifenacin in mixed urinary incontinence(MUI)patients in the 4th,8th and 12th week.Method:MUI outpatients were selected from the University of Traditional Chinese Medicine affiliated Dongzhimen Hospital Acupuncture and Moxibustion Department in between March 2014 to April 2015 as our research subjects.50 patients were randomly divided into 25cases of treatment group and 25 cases of control group through the clinical research central stochastic system.Treatment group received electroacupuncture in both Zhongliao(B35)and Huiyang(B35)acupoint,retained needle for 30 minutes,treated once every other day,3 sessions a week.Control group received PFMT with solifenacin.PFMT is divided into hospital Intense Exercise(IE)and House Exercise(HE),IE is for 45 minutes,once a week,HE is for 3 times daily,once every morning,afternoon and evening;Intake solifenacin once daily,1 pill at a time(5mg),continually treat both groups for 12 weeks.Primary outcome measures are urinary incontinence severity index and 72-hour incontinence episode frequency;Secondary outcome measures are the International Consultation on Incontinence Questionnaire-Short Form(ICIQ-SF),1-hour pad test,Incontinence Quality Of Life questionnaires(I-QOL),Incontinence Impact Questionnaires short form(IIQ-7)and Urongenital Distress Inventory(UDI)?The above measures were proceeded with data statistics,within and between groups in baseline,4th week,8th week and 12th week.Mainly to observe and evaluate the clinical therapeutic effect of electroacupuncture in MUI patients in different treatment periods.Results:(1)Primary outcome evaluation measuresUrinary incontinence severity index:Comparison within groups:? Score value of the treatment group in the 4th week of treatment compared to the baseline have decreased 5.56± 1.92;score value on the 8th week of treatment compared to the 4th week of treatment have decreased 2.84± 1.03;score value on the 12th week of treatment compared to the 8th week of treatment have decreased 1.36±0.49.All of the above results were shown with statistical significance(P<0.01).? Score value of the control group in the 4th week of treatment compared to the baseline have decreased 6.60± 1.80;score value on the 8th week of treatment compared to the 4th week of treatment have decreased 4.20± 1.38;score value on the 12th week of treatment compared to the 8th week of treatment have decreased 4.20±1.38.The above results have shown with statistical significance(P<0.01).This means that both the treatment group and the control group have therapeutic effect.Comparison between groups:The score value and the difference result gained within baselines in the treatment group and control group were compared in the 4th,8th and the 12th week of treatment.Both groups were compared between group in the 4th,8th and the 12th week.The score value of the treatment group was significantly higher than the control group,shown with the statistical significance in the difference(P<0.05).This means that the therapeutic effect of the treatment group is significantly better than the control group.72-hour incontinence episode frequency:Comparison within groups:?Score value of the treatment group in the 4th week of treatment compared to the baseline have decreased 5.56± 1.929.32±2.48;score value on the 8th week of treatment compared to the 4trh week of treatment have decreased 4,32± 1.93;score value on the 12th week of treatment compared to the 8th week of treatment have decreased 0.88± 1.24,All of the above results were shown with statistical significance(P<0.01).?Score value of the control group in the 4th week of treatment compared to the baseline have decreased 11.96±3.49;score value on the 8th week of treatment compared to the 4th week of treatment have decreased 11.96±3.49;score value on the 12th week of treatment compared to the 8th week of treatment have decreased 3.36± 1.87.The above results have shown with statistical significance(P<0.01).This means that both the treatment group and the control group have therapeutic effect.Comparison between groups:The score value and the difference result gained within baselines in the treatment group and control group were compared in the 4th,8th and the 12th week of treatment.Both groups were compared between group in the 4th,8th and the 12th week.The score value of the treatment group was significantly higher than the control group,shown with the statistical significance in the difference(P<0.05).This means that the therapeutic effect of the treatment group is significantly better than the control group.(2)Secondary outcome evaluation measuresInternational Consultation on Incontinence Questionnaire-Short Form(ICIQ-SF):Comparison within groups:?Score value of the treatment group in the 4th week of treatment compared to the baseline have decreased 8.68±2.21;score value on the 8th week of treatment compared to the 4th week of treatment have decreased 5.00±1.22;score value on the 12th week of treatment compared to the 8th week of treatment have decreased 1.56± 1.83,All of the above results were shown with statistical significance(P<0.01).? Score value of the control group in the 4th week of treatment compared to the baseline have decreased 10.56± 1.89;score value on the 8th week of treatment compared to the 4th week of treatment have decreased 7.32± 1.63;score value on the 1vtrh week of treatment compared to the 8th week of treatment have decreased 3.48± 1.66,The above results have shown with statistical significance(P<0.01).This means that both the treatment group and the control group have therapeutic effect.Comparison between groups:The score value and the difference result gained within baselines in the treatment group and control group were compared in the 4th,8th and the 12th week of treatment.Both groups were compared between group in the 4th,8th and the 12th week.The score value of the treatment group was significantly higher than the control group,shown with the statistical significance in the difference(P<0.05).This means that the therapeutic effect of the treatment group is significantly better than the control group.1-hour pad test:Comparison within groups:?Score value of the treatment group in the 4th week of treatment compared to the baseline have decreased 22.76±7.44;score value on the 8th week of treatment compared to the 4th week of treatment have decreased 10.88±3.81;score value on the 12th week of treatment compared to the 8th week of treatment have decreased 1.80±2.29,All of the above results were shown with statistical significance(P<0.01).? Score value of the control group in the 4th week of treatment compared to the baseline have decreased 27.84±7.73;score value on the 8th week of treatment compared to the 4th week of treatment have decreased 17.12±6.49;score value on the 12th week of treatment compared to the 8th week of treatment have decreased 8.00±4.70.The above results have shown with statistical significance(P<0.01).This means that both the treatment group and the control group have therapeutic effect.Comparison between groups:The score value and the difference result gained within baselines in the treatment group and control group were compared in the 4th,8th and the 12th week of treatment.Both groups were compared between group in the 4th,8th and the 12th week.The score value of the treatment group was significantly higher than the control group,shown with the statistical significance in the difference(P<0.05).This means that the therapeutic effect of the treatment group is significantly better than the control group.Incontinence Quality Of Life questionnaires(I-QOL):Comparison within groups:?I-QOL behavior limitation score value of the treatment group in the 4th week of treatment compared to the baseline have increased 19.40±2.89,score value on the 8th week of treatment compared to the 4th week of treatment have increased 25.76±3.26,score value on the 12th week of treatment compared to the 8th week of treatment have increased 30.44± 3.19;I-QOL psychological influence score value of the treatment group in the 4th week of treatment compared to the baseline have increased 22.52±2.92,score value on the 8th week of treatment compared to the 4th week of treatment have increased 30.12±2.45,score value on the 12th week of treatment compared to the 8th week of treatment have increased 36.08±2.83;I-QOL social barrier score value of the treatment group in the 4th week of treatment compared to the baseline have increased 15.12± 1.90,score value on the 8th week of treatment compared to the 4th week of treatment have increased 18.28± 1.57,score value on the 12th week of treatment compared to the 8th week of treatment have increased 21.52± 1.61,All of the above results were shown with statistical significance(P<0.01),which means treatment group have all shown with therapeutic effect..? I-QOL behavior limitation score value of the control group in the 4th week of treatment compared to the baseline have increased 18.00±2.52,score value on the 8th week of treatment compared to the 4th week of treatment have increased 23.12± 2.35,score value on the 12th week of treatment compared to the 8th week of treatment have increased 27.52± 2.43;I-QOL psychological influence score value in the 4th week of treatment compared to the baseline have increased 21.32 ± 2.10,score value on the 8th week of treatment compared to the 4th week of treatment have increased 28.24±2.71,score value on the 12th week of treatment compared to the 8th week of treatment have increased 32.56±3.11;I-QOL social barrier score value of the treatment group in the 4th week of treatment compared to the baseline have increased 14.20±2.14,score value on the 8th week of treatment compared to the 4th week of treatment have increased 17.08±2.14,score value on the 12th week of treatment compared to the 8th week of treatment have increased 19.56±2.16.The above results have shown with statistical significance(P<0.01).This means that the treatment group has all shown with therapeutic effect.Comparison between groups:Score value of both treatment and control group I-QOL behavior limitation,I-QOL psychological influence and I-QOL social barrier in the 4th,8th and the 12th week of treatment is compared with the difference value in baseline between both groups.The difference value of the treatment group is shown with statistical significance(P<0.05)and significantly higher than the control group when both groups are compared in the 4th,8th and the 12th week of treatment.This means that the therapeutic effect of the treatment group is significantly better than the control group.Incontinence Impact Questionnaires short form(IIQ-7):Comparison within groups:?Score value of the treatment group in the 4th week of treatment compared to the baseline have decreased 7.92±2.14;score value on the 8th week of treatment compared to the 4th week of treatment have decreased 4.52±1.45;score value on the 12th week of treatment compared to the 8th week of treatment have decreased 2.16±1.07,All of the above results were shown with statistical significance(P<0.01).? Score value of the control group in the 4th week of treatment compared to the baseline have decreased 8.08 ± 2.36;score value on the 8th week of treatment compared to the 4th week of treatment have decreased 5.72± 1.88;score value on the 12th week of treatment compared to the 8th week of treatment have decreased 3.68± 1.60.The above results have shown with statistical significance(P<0.01).This means that both the treatment group and the control group have therapeutic effect.Comparison between groups:The score value and the difference result gained within baselines in the treatment group and control group were compared in the 4th,8th and the 12th week of treatment.Both groups were compared between group in the 4th,8th and the 12th week.The score value of the treatment group was significantly higher than the control group,shown with the statistical significance in the difference(P<0.05).This means that the therapeutic effect of the treatment group is significantly better than the control group.Urongenital Distress Inventory(UDI):Comparison within groups:?Score value of the treatment group in the 4th week of treatment compared to the baseline have decreased 6.64± 1.41;score value on the 8th week of treatment compared to the 4th week of treatment have decreased 4.20±1.35;score value on the 12th week of treatment compared to the 8th week of treatment have decreased 2.12±1.17,All of the above results were shown with statistical significance(P<0.01).? Score value of the control group in the 4th week of treatment compared to the baseline have decreased 7.12 ±2.78;score value on the 8th week of treatment compared to the 4th week of treatment have decreased 5.48±2.10;score value on the 12th week of treatment compared to the 8th week of treatment have decreased 3.96±1.79.The above results have shown with statistical significance(P<0.01).This means that both the treatment group and the control group have therapeutic effect.Comparison between groups:The score value and the difference result gained within baselines in the treatment group and control group were compared in the 4th,8th and the 12th week of treatment.Both groups were compared between group in the 4th,8th and the 12th week.The score value of the treatment group was significantly higher than the control group,shown with the statistical significance in the difference(P<0.05).This means that the therapeutic effect of the treatment group is significantly better than the control group.Conclusion:1.Stimulating Zhong Liao and Hui Yang acupoint by electroacupuncture and PFMT with oral intake of solifenacin can effectively treat moderate severe female mixed urinary incontinence patients.2.According to the scoring in different treatment periods,the therapeutic effect of treatment group is more significant than the control group.Also,as the treatment duration extends,the therapeutic effect increased more significantly.3.As shown in the ICIQ-SF??-QOL and ?Q-7 results of MUI patients,electroacupuncture treatment can significantly increase the quality of life,improve the psychological state of the MUI patients than the control group. |
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