Uptake Of Evidence-based Statin Therapy Among Atrial Fibrillation Patients In China And Influencing Factors Analysis

Background: Atrial fibrillation(AF)is associated with increased incidence of cardiovascular disease,and hence,statin therapy is indicated in majority of AF patients.Methods: We analyzed data from the Chinese Atrial Fibrillation Registry(CAFR)involving 11496 AF patients from 2011 to 2014.Practice patterns of statin therapy and factors associated with statin underuse were analyzed.Results: Based on the 2013 ACC/AHA cholesterol management guidelines,statins should be recommended for 67.4%(7720/11461)of AF participants in CAFR,but only 43.4%(3352/7720)with appropriate indications were taking statins.Statin underuse in AF patients was independently associated with male sex,tertiary hospital treatment,outpatient attendance,and absence of ‘high risk' cardiovascular risk factors(overweight,diabetes,coronary heart disease,stroke/transient ischemic attack/peripheral embolism and hypertension).Conclusions: A high proportion of Chinese AF patients had indications for statin therapy.Evidence-based statin prescribing was suboptimal in this population.Greater efforts should be made to improve a holistic approach to cardiovascular risk management in the Chinese AF population.