| Section ⅠEffect of electro-acupuncture with different current intensities on functional constipationObjectiveTo evaluate the efficacy and safety of electro-acupuncture(EA)with different current intensities for patients with functional constipation(FC).And to assess whether the effects of EA with different current intensities are superior to the mosapride.MethodsPatients with FC were randomly divided into groups of low current intensity group(LCI,n=58),high current intensity group(HCI,n=65)and mosapride citrate control group(MC,n=67)at a ratio of 1:1:1.Patients in the electro-acupuncture groups received 16 sessions of acupuncture treatments in 4 weeks.Patients in MC were orally administered 5 mg mosapride citrate tablet 3 times daily for 4 continuous weeks if no severe adverse events were detected.The primary outcome was defined as both three or more spontaneous bowel movements(SBMs)per week and an increase of one or more SBMs per week from baseline for 3 or more weeks during 4-week treatment period.Secondary outcomes included the change from baseline of mean stool frequency(weekly rates of SBMs,stool consistency and severity of straining from week 1 to week 8),stool consistency,severity of straining during the 9 weeks of the study.A number of additional outcomes were assessed,including the proportion of patients who belong to severe constipation(defined as weekly SBMs less than 2 times per week),the strength of association between baseline values and the presence of primary outcome and weekly of SBMs>3 dichotomized as present/absent,the validated Patient Assessment of Constipation Quality of Life(PAC-QOL).Adverse events were also assessed.ResultsThe primary outcome was reached by 53.45%,66.15%,and 52.24%of the patients who received LCI,HCI and mosapride,respectively.EA can significantly improve the weekly SBMs(p<0.0001,all,while in LCI,at week 5 and week 8,p=0.001,p=0.0001,respectively),stool consistency(p<0.00,all,while in LCI,at week 1,p<0.01)and reduce straining severity(p<0.0001,all,while in LCI,at week 1,p<0.01 at week 3,p<0.001).HCI improved the quality of life better than mosapride(p<0.05),and reduced the proportion of severe constipation more than LCI and mosapride(p<0.05,both).EA had less adverse events(p<0.05).ConclusionsEA is effective and safe at both current intensities for FC,therapeutic effects of LCI and HCI are not superior to mosapride.EA is superior to mosapride in improving patients’ life quality and satisfaction level of treatment,EA has fewer adverse events than mosapride.Section ⅡSerum metabonomics preliminary study of electro-acupuncture with different current intensities in the treatment of functional constipationObjectiveTo study the serum metabonomics of the electro-acupuncture(EA)with different current intensities in the treatment of functional constipation(FC).MethodsThe total FC patients were 19(7,6,6,in low current intensity group,LCI,high current intensity group,HCL,mosapride citrate tablet control group,MC,respectively).Patients in the EA groups received 16 sessions of acupuncture treatments.Participants in this mosapride control group were orally administered 5 mg mosapride citrate tablet,3 times daily.Serum samples collected from the 19 patients before and after treatment.The orthogonal partial least square-discriminant analysis(OPLS-DA)was used to assess the metabolic data.Marked difference between the before and after treatment of FC were shown in OPLS-DA score plot.Variable important for project values(VIP)and T test were combined to pick out significant metabolic changes.Results:Among the three groups,the metabolites of VIP>1 were 11,7,21(in LCI,HCI and MC,respectively).Compared with that of before the treatment,the serum metabolites of patients were featured by increased level of L-Ornithine,Glyceric acid in LCI,and increased level of Vanillic acid in MC,while decreased level of Arabinonic acid in MC.ConclusionsThe effects of EA treatment on serum metabonomics of FC maybe are limited,further studies in need. |
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