Effect Of Moxibustion To Adjust Endocrine And Immune In Women With Pre-and Post Menopausal Status:A Clinical Study And Explanation Of Its Mechanism

Objective To observe the effect of moxibustion on acupoints of different body conditions,sub-health status of women before and after menopause,living conditions,emotional status,mental status,effects of sleep and quality of life,and to explore the intervention before and after different acupoints on endocrine,immune function,in order to select the best points,provide a theoretical basis for clinical prevention and treatment of postmenopausal Chinese medicine syndrome.Methods In accordance with the inclusion criteria 120 female volunteers before and after menopause in sub healthy were randomly divided into 4 groups,Guanyuan group,Sanyinjiao group,Shenshu group and VE group.Guanyuan group,Sanyinjiao group and Shenshu group respectively with mild moxa stick moxibustion,once daily,15min each time,5 days for 1 course of treatment,a total of 4 intervention treatment;VE group took vitamin E soft capsules,take one capsule daily for 28 consecutive days.Before and after the intervention were observed in the quality of life,physical condition,living conditions,emotional status,mental status and sleep status,and venous blood 5ml detection of serum sex hormone,anti Mullerian hormone,inhibin B and immune index.Results Moxibustion on Shenshu points can physical sub-health state of women before and after menopause was significantly improved(P<0.05)and living conditions(P<0.01).The curative effect is obviously superior to Guanyuan group,Sanyinjiao group and VE group.However,the four groups of emotional status and mental status were not significantly improved(P>0.05).From the sleep situation,before and after the intervention of sub-health state of Moxibustion in postmenopausal women to their sleep did not significantly influence the total score(P>0.05),but the Guanyuan group and Shenshu group on sleep wake up early in the the symptoms were improved significantly(P<0.05).The quality of life from the point of view,the quality of the table physical domain scores were significantly improved the survival of the four groups after the intervention(P<0.05),with Shenshu group was significant(P<0.01)and Shenshu group and VE group after the intervention of quality of life table total scores were significantly improved(P<0.01),Guanyuan group and Sanyinjiao group after the intervention of quality of life scale total score compared with before intervention,but there is no statistically significant improvement(P>0.05).Moxibustion on Guanyuan and Sanyinjiao,Shenshu could significantly increase serum E2 levels in postmenopausal women and sub-health status(P<0.05),in order to better effect of Shenshu group(P<0.01),compared with the VE group,there was a statistically significant.But FSH,LH and P of moxibustion,the adjustments are not obvious(P>0.05).Guanyuan group,Sanyinjiao group and Shenshu group were treated after 4 month treatment,the levels of AMH were increased(P<0.01),and VE intervention group after teatment had no significant difference.No significant improvement of moxibustion on serum INHB levels(P>0.05).The moxibustion Guanyuan obviously increased CD3+(P<0.05),reduce the level of CD8+(P<0.01);moxibustion Sanyinjiao can significantly improve CD3+(P<0.05),reduce the level of CD8+(P<0.05),and the ratio of CD4+/CD8+ increased significantly(P<0.05);moxibustion Shenshu acupoint can significantly increase serum CD3+(P<0.01),CD4 +(P<0.05)content,reduced CD8+(P<0.05)content,and adjust the ratio of CD4+/CD8+(P<0.05);group VE intervention can significantly reduce the content of CD8+(P<0.05),the ratio of CD4+/CD8+increased significantly(P<0.01).Conclusion Moxibustion on Guanyuan,Sanyinjiao,and Shenshu respectively can improve the quality of life,sub-health status of women before and after menopause in different degrees of sleep status,physical status and living conditions,to three points.The best effect of moxibustion Shenshu could significantly improve serum E2 and AMH levels in Shenshu Point is better,but the FSH and LH.P and INHB had no obvious effect.Three points are adjusted moxibustion can effectively regulate the immune cell T content,improve the immune function of sub-health status of women before and after menopause.