Literature Study Of Medication Regular Pattern Of Treating Hyperprolactinemia By TCM And A Summary Of Professor Li Kunyin’s Experience Of Treating Hyperprolactinemia

Objective1.Through systematical review of Chinese database collection,screening and finishing nearly thirty years related hyperprolactinemia clinical research literature,the prescriptions of traditional Chinese medicine law,provide systematic medication ideas for clinical treatment of hyperprolactinemia.2.Through three years of learning with the tutor,and the record copy experience,summed up Professor Li Kunyin’ s experience of treating hyperprolactinemia,so as for reference.Methods1.Select words such as "Hyperprolactinemia","hyperprolactinemia","galactorrhea-amenorrhea","Albright" to be the theme of a word or words in the China Journal Full-text Database(CNKI),VIP database(VIP),Chinese Wanfang database from January 1986 to December 2016 a comprehensive search of the literature.According to the inclusion criteria,excluding standard,strict selection of literature,and the standardization in literature data:record published year,whether to set the control group,treatment group sample size,number of treatment,whether combined with western medicine treatment or other therapy of Chinese medicine;key record of treating hyperprolactinemia composed of herbs,for high lactation endotoxemia and syndrome medication is not recorded.Standardization of traditional Chinese medicine and traditional Chinese medicine name,classification,classified by the method of reference Huang Zhaosheng editor of<>(pharmacy materials people’s Medical Publishing House,2002 First).To establish the basic information database by using Excel software,and prescription drug database,and classified by traditional Chinese medicine according to the classification,five flavours to establish sub database,the quantitative information input them;import it to SPSS18.0 statistical analysis software package,analysis,clustering analysis of data into the line number.2.In the process of learning with the teacher in the hard copy party,opinions,and record the experience,timely communication with teacher learning,from the etiology and pathogenesis,syndrome differentiation,summary of tutor’s experience and treatment characteristics,and through the typical case,layer by layer analysis of the therapeutic method.Results1.Literature study of medication regular pattern of treating hyperprolactinemia by traditional Chinese medicine1.1 General informationThis paper collected nearly thirty years(1986 to 2016)of the document,in accordance with the inclusion criteria 61 articles altogether,first published in 1993,the number of up to 2016,six.36 of which are in the process of research set up the control group,59.0%.treatment group accounted for the sample size of at least 20 cases and most were 366 cases.The sample of 30 cases(18%),the most common literature sample of 36.07%in 30 cases of-39 cases of.55 documents is the use of unilateral treatment,the remaining 6 articles for syndrome differentiation.All the literature of the treatment group were less than traditional Chinese medicine,the treatment group 65.6%literature is a pure Chinese medicine treatment.The research course is less than 3,the majority of research for a period of one month,the total course length is almost within 6 months,with 3 months of treatment length is more common.1.2 Analysis of medication regular patternThe 61 articles included a total of 107 traditional Chinese medicines,the total number of drugs for the taste of the times,the average use of Chinese herbal medicine for each of the 6.7 flavors.Each prescription using 4-26 Chinese medicine,the average use of Chinese herbal medicine on the average of the 11.75 flavors.1.2.1 Classification and frequency analysis of traditional Chinese Medicine107 herbs belonging to 16 categories in traditional Chinese medicine,which belongs to the tonic medicine most taste(29 flavors of Chinese medicine,the use frequency of a total of 284 times,accounting for 39.61%of the total drug frequency);followed by blood stasis(13 herbs,frequency up to 75 times).The number of Chinese top five.Also rational gas medicine,antipyretic,relieving cough and asthma drugs,including 11,10,10 herbs,frequency were 55 times,58 times,29 times.The number of species of Chinese medicine ranked seventh,eighth,Ninth dampness medicine,drug digestion,relieving drugs,the use of high frequency(44 times,65 second,53 times),the average of each medicine use frequency were 8.8 times,16.25 times,13.25 times.The average frequency of traditional Chinese medicine was used as the standard,and the average frequency was from high to low.1.2.2 Analysis of high frequency Chinese medicine by categoryEach category of traditional Chinese medicine were established in sub database,according to the frequency of use of traditional Chinese medicine,sort of the class from high to low,the cumulative frequency of more than 50%are satisfied for the high frequency of traditional Chinese medicine for traditional Chinese medicine category.The total frequency of less than 10 categories,there is no high frequency.The final analysis of traditional Chinese medicine obtains the high frequency unified medicine category the list:peony,licorice,angelica,Atractylodes,medlar,radix,radix curcumae,Rhizoma Cyperi,radix salviae miltiorrhizae,Fructus aurantii,peony root,red peony root,gardenia,pinellia,dogwood,Poria,malt,bupleurum.The total frequency of the hematonic accounted for nearly half of the tonic medicine in this category(41.55%),followed by the qihm.1.2.3 Tropism analysis of Chinese herbal medicineThe Chinese medicine four belonging to warm medicine(up to 43 kinds of traditional Chinese medicine,the cumulative frequency of 248),followed by cold medicine(34 herbs,the cumulative frequency of 238),neutral medicine again(23 herbs,the cumulative frequency of 213(4).Hot medicine herbs,the cumulative frequency of 9),cool medicine(3 herbs,the cumulative frequency of 9)a small number.The traditional Chinese medicine five flavor to sweet medicine home,most(61 kinds of traditional Chinese medicine,the cumulative frequency of 484),bitter times(45 herbs,the cumulative frequency of 326),pungent drugs again(40 herbs,the cumulative frequency of 275),the three medicines of the cumulative frequency of 1085 times,accounting for 85.5%.and sour drugs although only 8 flavor,has 106 times the frequency,the frequency is also quite mild.Drugs,salty medicine,type and frequency of astringency is less.The traditional Chinese medicine meridian,liver meridian in medicine(up to 66 herbs,frequency of 534,the total frequency of 61.68%).Followed by spleen(34 herbs,frequency 342),kidney(44 herbs,frequency 259),although the number is less than the spleen by medicine taste kidney medicine,but compared with the high frequency of use according to the second position,the heart again.(29 herbs,frequency 209),stomach(32 herbs,frequency 183).The liver,spleen,kidney,heart,stomach medicine total frequency of a total of 1527,more than the total number of 83.99%.owned by the drug frequency is low.1.2.4 Analysis of high frequency Chinese medicine in the whole medicineAccording to the frequency from high to low order,the frequency of traditional Chinese medicine is higher than 7 times(that is,the frequency of the use of the drug is not less than 1%),it will be for the whole drug in the high-frequency Chinese medicine:Peony(53 flavour),malt(49 flavour),Radix Bupleuri(taste 49 times(47 times),angelica,Poria(taste)taste 35 times(26 times),licorice flavor),Cyperus rotundus(25 flavour),Baizhu(18 flavour),medlar(taste 18 times).Achyranthes(18 flavour),Epimedium(17 flavour),Radix Rehmanniae(16 flavour),peony bark(16 flavour),dodder(15 flavour),dogwood(15 flavour),yam(14 flavour),hawthorn(12 flavour),turmeric(11.(10 times),Salvia miltiorrhiza,Radix Paeoniae Rubra(flavour)taste 10 times(10 times),pinellia tuber taste),gardenia(9 flavour),Radix Rehmanniae(8 flavour).There are 9 kinds of tonic medicine,4 kinds of heat clearing drugs,3 kinds of medicine,2 kinds of digestion medicine,and tonic medicine include blood medicine 3 flavor,qihm 3 flavor.23 taste high-frequency drug concentration in the cold,warm,smooth;its taste in sweet,bitter,spicy.The most common acid,sweet;mainly into the liver,kidney,spleen,heart,stomach,focus on the liver.1.2.5 Cluster analysis of traditional Chinese medicine for the treatment of hyperprolactinemiaAccording to the dendrogram,the four combinations:C1:Radix Paeoniae Alba,Radix Bupleuri,angelica,Atractylodes,licorice,malt.C2,Rhizoma Cyperi,Poria.C3:epimedium,medlar,dodder,turmeric,pinellia,hawthorn,Salvia miltiorrhiza,radix paeoniae rubra,Radix.C4:Moutan,Fructus Gardeniae,radix rehmanniae,Cornus officinalis,yam four,Shudihuang.Clustering combination can be summed up the Chinese medicine for the treatment of basic hyperprolactinemia,and coherent,Bushenhuoxue square,square fire Yin.2.A summary of Professor Li Kunyin,s experience of treating hyperprolactinemiaProfessor Li Kunyin believes that the important pathogenesis of hyperprolactinemia is liver and kidney disharmony,kidney deficiency and liver stagnation,in prescription,uphold the homology center according to the liver and kidney,and permit the chmical process;medication often choose malt,tangerine peel,turmeric,Radix Paeoniae Alba,Radix Bupleuri,and allowing the economy to get sick inquiry ability people under the condition of adding a pangolin improved;according to the woman the stage,sometimes on medication,and staging conditioning;do not rigidly adhere to a method,combined with western medicine bromocriptine mesylate tablets,vitamin B6 and so on,full participation in the west,in order to reduce the serum prolactin levels of patients.Conclusion1.Chinese medicine for the treatment of hyperprolactinemia in the clinical literature in recent thirty years,Chinese medicine often choose tonic,sweet taste,the medication ideas closely around this theme of Shuganjieyu,syndrome differentiation,or kidney,or spleen,or dampness,or stasis,delactation and inducing or increasing menstruation.2.In the treatment of hyperprolactinemia,Professor Li Kunyin judges the pathogenesis of hepatorenal homology,uses certain characteristic medicines,prescripes according to the stage,and combines traditional Chinese medicine and western medicine.