| Objective:To Bone remodling decoupled diseases,usually adopt the drug treatment which can pure inhibit bone resorption or stimulate bone formation,but the clinical efficacy is not good enough. The reason is that the unilateral inhibiting bone resorption can inhibit bone formation,at the same time, the unilateral stimulating bone formation would also strengthen bone resorption.This goes to show the point that the single interference or influence of bone remodeling process of broken bone or osteogenesis will destroy the balance of bone remodeling coupling mechanism.So, academic circles put forward "synergy" (synergetic) concept, and advocate the new treatments development to rebuild bone remodeling coupling balance.In this study the "Shaoyang governing bone" theory advocated by the fifth batch of old Chinese medicine expert professor Wang Hongdu as the core, the traceability and finishing Wang Hongdu teacher "Shaoyang governing bone" theory,academic thoughts and clinical experience which treat " The Illness Of Bone Shaking Or Fragile"(Mainly Bone Remodling Decoupled Diseases,such as osteoporosis) by use reconciling Shaoyang method. In order to provide theoretical basis and new treatments for Bone remodling decoupled diseases.Methods:Learning from the teacher:at clinical, perserve and observing teacher use of inspection, auscultation,olfaction, inquiry, pulse-taking and palpation carefully;taking notes carefully; considering after diagnosis, writing learning experience, summarizing the medical record, taking the teacher’s dialectical ideas and basis for rational use of Chinese herbsB. Reading the teacher’s pubications:studying teacher published publications carefully, combining the academic views of publications with the learning experience by the teacher, putting the theory and practice together, finally if I have any doubt, I would ask for the mentor, to deeper understand the teacher’s academic thoughts.C. Learning the origin related bibliography which teacher academic theory comes from:intensively reading the bibliography listed by teacher, tracing the origin of teacher’s academic theory, in order to more fully understanding the teacher’s academic theory.D. Apply:Apply teacher’s academic theories flexibly at clinical practical, and on the basis of research at the early stage,use a randomized controlled, choose sensitive indicators of bone resorption and bone formation,and other related indicators to carry out clinical trials, let the theory feedback in the form of clinical studies,consequently,achieve the process of theory,clinical,theory;so that I have a good understand of teacher’s clinical academic theory.Content:The origin of academic theory of "ShaoYang governing bone"discovered by professor Wang Hongdu and the research progress of "The Illness Of Bone Shaking Or Fragile"(Mainly Bone Remodling Decoupled Diseases,osteoporosis).Professor Wang Hongdu is good at use the meridian syndrome differentiation, eight principles and differentiation,viscera-syndrome differentiation together, using acupuncture and Chinese medicine to treat arthritis and musculoskeletal diseases. Academic theory called "ShaoYang governing bone" advocated by the teacher comes from <Huangdi Neijing>. Integrating the sorting literature and research include the theory of dispersion in the text of the pooled all previous dynasties famous note view with the latest modern medicine achievements of bone disease and bone biology (with "ShaoYang governing bone", corresponding with modern medicine called "bone remodeling coupling loss bone disease",such as the most common "osteoporosis" very similar) construct the special bone disease cure approaches and research ideas and methods,and get through a series of scientific researches, including the national natural science fund project,in verifying the academic point of view, the interpretation of the pathophysiological mechanisms and clinical practice.All from animal experiments to clinical studies had revealed objectively and completely the mysterious connotation, resetting the theory to clinical reality, eventually restoring its theoretical position and use value.In 1990s, the international academic circle of bone biology obtained breakthrough of bone remodeling process of osteoclasts, and osteoblasts coupling process.Once bone remodeling decoupled,it would evolve into common pathological basis of a variety of metabolic bone diseases,such as cancerous solvent bony damage, rheumatoid arthritis, osteoporosis, etc..These are the abnormal function of osteoclast activity and relatively osteoblast function caused by insufficient;however, ankylosing spondylitis, psoriasis arthritis, diabetes, charcot arthropathy, etc.and family autosomal recessive inherited gene defects, such as narrow sclerosing (sclerosteosis) and Van der bucher’s disease (Van Buchen diseases), its are because the osteogenetic ability over the broken bone.Drug treatment can only use to inhibit purely bone resorption and stimulate bone formation,for some of above bone diseases over the years.But because the unilateral inhibiting bone resorption will prevent bone formation and unilateral stimulates bone formation also can increase along with the bone absorption, the effects are not so good.In osteoporosis, for example, two phosphonic acids can effectively inhibit bone absorption, increase bone mass, but can not reduce fracture rate.Long period of treatment cause more debilitating fragile bone formation, make the fracture repair difficult, and resist bone anabolic drugs.Using continuously bone anabolic drugs, such as parathyroid hormone (PHT) can enhance bone formation and increase bone resorption, but the result still losses bone mass.So recent academic circles put forward the concept of "synergetic",the same meaning of coordination, calling for being committed to developing to rebuild bone remodeling coupling balance of new treatments.Use traditional Chinese medicine to treat bone diseases,always emphasizing the "kidney governing bone",so the prescription of traditional Chinese medicine or acupuncture and moxibustion almost always follow the theory.Animal and human experiments also show these have the effect of inhibiting bone resorption, and some studies refer to the function of osteoblast, but most of these start from some cytokines to OB’s unilateral effects, with not refer to balance bone remodeling complex function of the coupling.b. organizing and researching the professor Wang Hongdu "Shao Yang governing bone" theory academic thoughts and clinical experience.Professor Wang Hongdu beginning from huangdi neijing "Shao Yang governing bone", explores and validates relationship between the shaoyang meridian and pathology of the skeletal system in whole body bone strength physical, clarifies its mechanism that is "and" the balance of bone remodeling process, namely the view of neijing "shaoyang pivot".In addition, Shaoyang principal bone being similar to the clinical characteristics of bone pain, should be more parts and has the characteristics of the week’s sex.Further,he expounds the little Yang meridians and physiological and pathological relationships between the skeletal system, "little Yang primary bone" and "kidney advocate bone" relationship and less Yang "the end" "discount" in the real world of objective existence.Comb "Shao Yang governing bone" history of the doctrine of fugitive dust, clarify its physiological and pathological connotation and significance, and the corresponding disease clinical prototype, construct the corresponding theory model.The annihilation "Shao Yang governing bone" theory in thousands introduced modern scientific research, selecting appropriate animal models and laboratory indexes, "Yang" less settlement as the solution,we design clinical trials on the basis of the electric acupuncture foot shaoyang meridian and classic "small bupleurum decoction",meanwhile,choose a variety of functional and morphological indexes, with the purpose of proving that less Yang and small bupleurum decoction together intervention have effects on bone remodeling in rats;And prove that less Yang by the circadian rhythm is associated with bone remodeling process.We plan to establish a "reconciliation Shao Yang" new mode as the main treatment for bone disease, and clinical treatment scope expanded to the primary osteoporosis and bone balance disorder of knee osteoarthritis, and fluorine sex osteoarthritis, etc. Forming in "Yang" less settlement for solution, integrating inside governance with outside governance, acupuncture with Chinese medicine, we are to creat comprehensively the new situation which treats bone remodeling coupling loss of bone disease. c. The "Yang" less settlement method for knee osteoarthritis with osteoporosis clinical research.In this study, "Shao Yang governing bone" advocated by Wang Hongdu teacher as the guiding, from the Angle of clinical trials, echo "Yin and Yang" and "holy and degree" and "shaoyang pivot" point of view, we adopts the Lysholm knee scoring system and WOMAC score system combining with bone metabolism and biochemical indicators (BALP, BGP, TRAP and TNF, IL-1-a, etc.), in order to verify further that the mechanism of the "little Yang primary bone" is the same as "and" bone remodeling proces.Conclusion:In Chinese academic circles, "Shao Yang governing bone" theory has been the eternal puzzles, the professor Wang Hongdu demonstrates "resurrection" neijing "little Yang primary bone" theory, by validation of scientific experiments on the exactly, and clarifying preliminarily its mechanism on the clinical application.He puts forward that modern medicine on the clinical manifestations of the so-called "bone remodeling coupling loss bone disease" is extremely similar to the unbalance of "Shao Yang governing bone", which expands its adapt to the disease.expands foot ShaoYang and acupuncture point features and application, enriches the basic theory of Traditional Chinese medicine, bone physiological pathology,etc.a. According to the view of "Yin and Yang" and, "reconciling method is the best " and "shaoyang pivot", and considering experiment research about the foot shaoyang meridian and "Yang" less settlement small bupleurum decoction on bone remodeling coupling of bone disease, under the leadership of professor Wang Hongdu,we put forward that the mechanism of the "Shao Yang governing bone" is "reconciling" bone remodeling process.The "reconciling" mechanism will provide new "synergy" method of prevention and cure for osteoporosis, diabetes foot and cancerous tumors dissolved bone damage, and other bone remodeling coupling loss of bone disease (freedom of bone disease).b. Clinical studies have shown that guiding by the "Shao Yang governing bone", focusing on "reconciling",we can regulate bone remodeling coupling, the Yin and Yang, loss more than not enough,to rebuild bone resorption and bone formation of dynamic balance, which are beneficial to solve the problem when we face with pure resistance to bone resorption or promote bone synthesis doses dilemma,which open up a new way to cure the variety of bone disease in traditional Chinese medicine acupuncture and medication for the future. |
