| [Research Objective]Professor Lin xianglin,an academic experience inheritance guidance teacher of the fourth and fifth batch national famous old Chinese Medicine Doctor,Guizhou province,engaged in clinical、teaching and scientific research work for 40 years. He has accumulated rich clinical experience, gradually developed into a focus on thecharacteristics of balance of law and his own unique of academic thought,he is good at treating internal diseases, senile diseases and gynecological diseases, he is a well-known Chinese medicine diseases expert inside and outside of the province, he has unique experience in the treatment of spleen and stomach disease from fruitful result.The academic thoughts and clinical experience of Professor Lin Xiangli is a valuable asset.Therefore, the purpose of this study is to summarize the academic origin, academic thoughts and clinical experience of Professor Lin Xiangli’s differentiation of spleen and stomach. And,to analyze the medicine rule of the four represent diseases of spleen and stomach diseases,such as stomachache, fullness in full, constipation and diarrhea based on TCM inheritance auxiliary platform.To Explore,study and research the academic thought and clinical experience of the old Chinese medicine doctor in order to better summarize, inherit and develop the academic thought and clinical experience of Professor Ling Xiangli,which can not only improve their academic level and clinical reasoning ability but also can further benefit patients and society, plays a special role in the academic heritage of traditional Chinese medicine experts in traditional Chinese medicine.[Research method and content]This subject mainly concludes arranging academic,clinical experience origin, clinical experience and swelling the medicine rule of stomachache, fullness in full, constipation and diarrhea of Professor Ling Xiangli.Collected outpatient medical records and treatment prescription, teachers’lecture materials and dissertation by following outpatient,Summarized teacher’s academic origin,thoughts of spleen and stomach disease and clinical experience by combining with teachers’ specific interview and own clinical practice and studying literature.The prescription and medicine records of Professor LinXiangli’s stomachache,swelling of the liver full,constipation and diarrhea from 2010 January to July 2015 were collected into traditional Chinese Medicine Inheritance support system(v2.5) version,analyzed the medicine rule and explored the new method by using the software set the frequency statistics,association rule,complex system entropy clustering method,improved mutual information method and unsupervised hierarchical entropy clustering etc.[Research result]Part 1 Academic Origin of Professor Lin XiangliAcademic origin of Professor Lin Xiangli mainly from two aspects,the first aspect is the heritage of the Hunan Medical Ouyang Lvqin, Ouyang Qi’s balance theory, disease and syndrome binding and often change. Secondly,base on this, on the other hand, Professor Ling Xiangli researched Neijing, Shanghan Lun, Synopsis of prescriptions of the Golden Chamber and Spleen and stomach, gradually formed her own unauthorized method, differentiation characteristics of force balance adjustment, pay attention to the viscera theories, attach importance to the combination of disease and syndrome, to emphasize often change up.Part 2:Summarize Academic Thoughts and Clinical Experiment of Professor Lin XiangliSummarized professor Lin xiangli’s differentiation on treating spleen and stomach pay attention to combination of the four methods of diagnosis,especially tongue diagnosis, always checking for cause, distinguish primary and secondary, and to keep the disease machine, pay attention to the combination of disease and symptom, clinical use and method, and strive to balance the and cure the spleen and stomach did not forget to emotional adjustment is good at seize the key pathogenesis, focus on the whole, restore the function of the spleen and stomach,and plays the advantage of Chinese and Western Medicine.Part 3 Analyze Professor Lin xiangli’s medicine rule of spleen and stomach disease based on Chinese Medicine Inheritance support systemChapter One:Analyze Professor Lin xiangli’s medicine rule of spleen and stomach disease based on Chinese Medicine Inheritance support systemFrequency statistics and correlation algorithm showed that the drugs which Professor Lin used to treat stomache are the follows:Christina Loosestrife, oriental wormwood, Radix Paeoniae Alba, Rhizoma Cyperi, Fructus aurantii, liquorice, Rhizoma Atractylodis Macrocephalae, fried malt, fried millet sprout, bupleurum root, curcuma root, Poria, Radix Scutellariae, Amomum villosum etc., these drugs mainly to Qi Qi, clearing heat and dampness, supplementing qi and nourishing Yin, promoting blood circulation and pain is given priority. Association rules with the support of a number 107 conditions, drug combination frequency table in the combined ranking:Artemisia capillaris Herba Lysimachiae; Radix Paeoniae Alba, Herba Artemisiae Scopariae; Radix Paeoniae Alba, Herba Lysimachiae; fried malt, fried Guya; Radix Paeoniae Alba, Fructus aurantii, Radix Paeoniae Alba, radix, Radix Paeoniae Alba, Herba Artemisiae Scopariae, Lysimachia, Fructus aurantii etc.. Confidence> 0.98,Drug combinations of association rules discovery fried millet sprout, fried malt must be used at the same time; Radix Bupleuri, Fructus aurantii and Herba Artemisiae Scopariae or Christina Loosestrife herb with, in most cases will combined with Radix Paeoniae Alba and other rules. The association rules are the core of drug network show the Christina Loosestrife, oriental wormwood, Radix Paeoniae Alba, Radix Bupleuri, Rhizoma Cyperi, Fructus aurantii, liquorice, Rhizoma Atractylodis Macrocephalae, fried malt, fried millet sprout, turmeric root tuber, Poria, Radix Scutellariae is Xiang Li Ling, a professor in the treatment of stomachache of Shugan Hewei decoction prescription for core. Formation of the seven new prescriptions, bamboo shavings, teasel root, dodder, ridge sheet; Ⅱ cuttlebone, and white, Radix Peucedani, Dabei; Ophiopogon japonicus, Glehnia littoral is, polygonatum odoratum, betel nuts, coke hawthorn; 4 rugosa, Caulis Polygoni Multiflori, Pericarpium Arecae, perilla seed; fifthly, Fructus aurantii Immaturus, Coptis chinensis, Magnolia officinalis, Pericarpium Arecae, perilla seed; sixthly, lophatherum gracile, Akebia, Platycodon grandiflorum, Fructus Arctii; seventhly, Radix Aucklandiae, Radix Paeoniae Alba, pinellia tuber, dried tangerine peel, Poria, Radix Codonopsis, Amomum villosumChapter 2:Analyze the pattern of differentiation full prescription based on theinheritance of traditional Chinese medicine auxiliary system of Professor Lin XiangliAssociation rules and frequency statistics analysis showed that the drugs which Ling Xiangli professor commonly used to treat are the follows:Desmodium, Radix Paeoniae Alba, Yin Chen, fried, fried malt sprout, bupleurum, Cyperus, Fructus aurantii, white atractylodes rhizome, etc.. Association rules with the support of a number of 33 conditions, drug combination frequency table rankings in combined:Artemisia capillaris Herba Lysimachiae; fried malt, fried Guya; Radix Paeoniae Alba, Rhizoma Cyperi, Radix Paeoniae Alba, Herba Artemisiae Scopariae and Lysimachia christinae; Radix Paeoniae Alba, fried millet sprout, fried malt; Radix Paeoniae Alba, Fructus aurantii, Cyperus rotundus, trifoliate orange shell. Drug combinations association rules find fried millet sprout and fried malt certain with, Radix Paeoniae Alba, Herba Artemisiae Scopariae (or Rhizoma Cyperi) at the same time will use Lysimachia virgate wormwood herb, Fructus aurantii with will use Lysimachia rules. Association rules core drug network display icon fried millet sprout, fried malt, Radix Paeoniae Alba, Rhizoma Cyperi, virgate wormwood herb, Herba Lysimachiae, drug Fructus aurantii is the core. Based on entropy hierarchical clustering of the treatment of Piman candidate new prescription:bamboo shavings, Evodia rutaecarpa, cassia seed, Rhizoma alismatis; secondly, bamboo shavings, coptis root, Alisma tuber, pinellia; Gualou shell, white atractylodes rhizome, Radix Polygoni Multiflori, cassia; Radix dipsaci, citron, jujube peel, Clematis; fifthly, citron, dodder, polygala root, Rhizoma Atractylodis, Euryale ferox; sixthly, forsythia, honeysuckle flower, raw hawthorn, the Divine Comedy, areca leaves; seventhly, Ophiopogon japonicus, Scrophularia root, cassia twig, Glehnia littoralis; the, mulberry leaf, honeysuckle, Rhizoma Dioscoreae Hypoglaucae; anlyses of Hedyotis diffusa Willd, Caulis Spatholobi, dandelion, glossy privet fruit, Scutellaria barbata.Chapter 3:Analyze the pattern of constipation prescription based on theinheritance of traditional Chinese medicine auxiliary system of Professor Lin XiangliAssociation rule algorithm and frequency statistics showed that the drugs which Pofessor Lin commonly used to treat constipation are the follows:Trichosanthes shell, white atractylodes rhizome, licorice root, raw land, angelica, chuanxiong, cassia seed, Fructus aurantii Immaturus and Radix Codonopsis, citrus aurantium, hemp seed, astragalus root, aster, Radix Paeoniae Alba, arborvitae seed, dwarf lilyturf root, turmeric root tuber, raw hawthorn, Radix Scrophulariae, fried malt, Bupleurum root, snakegourd seed. Association rules with the support of 15 conditions, drug combination frequency display Trichosanthes shell are respectively connected with the students, cassia seed, Ren Fructus Trichosanthis, combination of Tatarian aster root, figwort, Ophiopogon japonicus, Magnolia, Fructus aurantii, Fructus aurantii Immaturus; there are also students respectively and figwort root, magnolia bark, grass will Ming, aster, ophiopogon root, Fructus aurantii Immaturus and Fructus aurantii, snakegourd seed combination combination in the combined ranking and a number. Drug combinations association rules show Ling teacher Xiangli in the treatment of constipation following certain with:Ren Fructus Trichosanthis, Trichosanthes shell; raw land, Ren Fructus Trichosanthis and Trichosanthes shell; Ren Fructus Trichosanthis, Cassia obtusifolia and Trichosanthes shell; aster, raw land, Trichosanthes shell and Radix Scrophulariae and so on. Based on hierarchical clustering based on entropy for the treatment of constipation of candidate new prescription 7, Schisandra, mint, Radix dipsaci, Glehnia littoralis, Hedyotis diffusa Willd; Ⅱ hemp seed, aster, raw hawthorn, licorice root, peppermint, stir fried malt, immature bitter orange, magnolia bark, Radix Scrophulariae, fried millet sprout; 4, figwort root, officinal magnolia bark, Rhizoma Cyperi; fifthly, cassia, pinellia, raw hawthorn, Scutellaria barbata, Hedyotis diffusa Willd; sixthly, asparagus, Suanzaoren, Trichosanthes shell, pilose asiabell root, lotus leaf; seventhly, Radix Paeoniae Alba, turmeric.Chapter 4:Analyze the rule of differentiation diarrhea prescription rule based on theinheritance of traditional Chinese medicine auxiliary system of Professor Lin XiangliAssociation rule algorithm and frequency statistics showed that the drugs which Pofessor Lin commonly used to treat diarrhea are the follows::fried largehead atractylodes rhizome, tuckahoe, yam, millet sprout stir fry, fried malt, radix curcumae, Radix Glycyrrhizae, Radix Paeoniae Alba, amomum fruit, pilose asiabell root, Schisandra, parched hawthorn fruit, oriental wormwood, Christina Loosestrife herb, Pericarpium Citri Reticulatae, coix seed, Balloonflower root, pinellia, fried lentils, Cyperus rotundus, and other. Association rules in support of a number for the 15 conditions, drug combination frequency display ranking in the combined have fried largehead atractylodes rhizome and yam, Poria, fried millet sprout, fried malt, curcuma root, white peony root, amomum fruit, tangerine peel, pilose asiabell root, the combination of Fructus schisandrae chinensis; malt stir fry, fried millet sprout and tuckahoe, yam, Fructus crataegi Preparata and combination. Drug combinations association rules show Ling Xiangli teacher treatment of diarrhea following drug must be applicable:fried lentils and poria cocos; stir fried millet sprout and fried malt; stir fried white atractylodes rhizome, Chinese yam, Poria, charred Fructus crataegi and fried buds with. Formation of twelve new prescription, Imperata root, Polygala, Polygonum aviculare, prepared rhubarb; Ⅱ Stemona, cardamom, Rhizoma Atractylodis Macrocephalae, Sanguisorba carbon; stir fried malt, dogwood, windproof, fried Guya; Radix Paeoniae Alba, angelica, Radix Saposhnikoviae, Radix Bupleuri; fifthly, Amomum villosum, licorice root, dipsacus root, Dangshen, Guang Xiang Mu; sixthly, Poria cocos, Codonopsis pilosula, Costus root, Cyperus rotundus; seventhly, Poria cocos, dried tangerine peel.[Conclusion]1.Through three years of learning of teacher’s papers, lecture materials as well as cmbination with the special interview of teacher, the teacher academic origin, and treating spleen and stomach disease academic thoughts and clinical experience are summarized. Proposed the use of Professor Ling Xiangli and the law, and strive to balance the academic thinking of the core. At the same time, in their own clinical practice, the full use of the teacher’s academic thought and clinical experience, clinical efficacy is more obvious, to achieve the teacher’s academic thought and clinical experience for effective inheritance and development of the purpose, through the study of the Chinese medicine, their clinical thinking ability and academic level has been greatly improved.2.The built-in frequency statistics, association rule, complex system entropy clustering method, improved mutual information method and unsupervised entropy hierarchical clustering etc. data mining methods base on TCM inheritance auxiliary platform provide a new scientific method for the typical precicription of old Chinee Medocine teacher’s diagnosis and treatmen of spleen and stomach disease.The reult of data mining results are nearly same as old traditional Chinese Medicine Doctors’smmarization results of academic thought of,and Professor Lin also think so.Therefore, the traditional Chinese medicine data mining based on old Chinese Medicine support standard has important significance on exploration, analysis and research of academic thought and clinical experience of the famous old Chinese medicine and better guide and discover the regularity as well as mining the new prescripation.This method can provide some objective basis for clinical practice, and also can provide a reference for the current academic thought and clinical experience of old famous Chinese Medicine Doctor. |
